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https://hdl.handle.net/2440/106794
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dc.contributor.author | Yang, G. | - |
dc.contributor.author | Wibowo, D. | - |
dc.contributor.author | Yun, J. | - |
dc.contributor.author | Wang, L. | - |
dc.contributor.author | Middelberg, A. | - |
dc.contributor.author | Zhao, C. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Langmuir: the ACS journal of surfaces and colloids, 2017; 33(23):5777-5785 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.issn | 1520-5827 | - |
dc.identifier.uri | http://hdl.handle.net/2440/106794 | - |
dc.description.abstract | Silica nanocapsules have attracted tremendous interest for encapsulation, protection, and controlled release of various cargoes due to their unique hierarchical core−shell structure. However, it remains challenging to synthesize silica nanocapsules having high cargo-loading capacity and cargoprotection capability without compromising process simplicity and biocompatibility properties. Here, we synthesized oil-core silica-shell nanocapsules under environmentally friendly conditions by a novel emulsion and biomimetic dualtemplating approach using a dual-functional protein, in lieu of petrochemical surfactants, thus avoiding the necessities for the removal of toxic components. A light- and pH-sensitive compound can be facilely encapsulated in the silica nanocapsules with the encapsulation efficiency of nearly 100%. Release of the encapsulated active from the nanocapsules was not shown an indication of undesired burst release. Instead, the release can be tuned by controlling the silica-shell thicknesses (i.e., 40 and 77 nm from which the cargo released at 42.0 and 31.3% of the initial amount after 32 days, respectively). The release kinetics were fitted well to the Higuchi model, enabling the possibility of the prediction of release kinetics as a function of shell thickness, thus achieving design-for-purpose silica nanocapsules. Furthermore, the nanocapsules showed excellent alkaline- and sunlight-shielding protective efficacies, which resulted in significantly prolonged half-life of the sensitive cargo. Our biomimetic silica nanocapsules provide a nanocarrier platform for applications that demand process scalability, sustainability, and biocompatibility coupled with unique cargo-protection and controlled-release properties. | - |
dc.description.statementofresponsibility | Guang-Ze Yang, David Wibowo, Jung-Ho Yun, Lianzhou Wang, Anton P.J. Middelberg, and Chun-Xia Zhao | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.rights | © 2017 American Chemical Society | - |
dc.source.uri | http://dx.doi.org/10.1021/acs.langmuir.7b00590 | - |
dc.subject | Silicon Dioxide | - |
dc.subject | Emulsions | - |
dc.subject | Delayed-Action Preparations | - |
dc.subject | Biomimetics | - |
dc.subject | Nanocapsules | - |
dc.title | Biomimetic silica nanocapsules for tunable sustained release and cargo protection | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/acs.langmuir.7b00590 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP150100798 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT140100726 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Yang, G. [0000-0002-6194-1918] | - |
Appears in Collections: | Aurora harvest 8 Chemical Engineering publications |
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