Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106820
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Type: Journal article
Title: Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation
Author: Le Leu, R.
Young, G.
Hu, Y.
Winter, J.
Conlon, M.
Citation: Digestive Diseases and Sciences, 2013; 58(12):3475-3482
Publisher: Springer US
Issue Date: 2013
ISSN: 0163-2116
1573-2568
Statement of
Responsibility: 
Richard K. Le Leu, Graeme P. Young, Ying Hu, Jean Winter, Michael A. Conlon
Abstract: BACKGROUND: Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease. AIMS: The aim of this study was to determine the effects of feeding a red meat diet with and without resistant starch (RS) to mice with dextran sulfate sodium (DSS)-induced colitis. METHODS: Colonic experimental colitis was induced in Balb/c mice using DSS. The severity of colitis was evaluated based on a disease activity index (based on bodyweight loss, stool consistency, rectal bleeding, and overall condition of the animal) and a histological score. Estimations were made of numbers of a range of different bacteria in the treatment pools of cecal digesta using quantitative real-time PCR. RESULTS: Consumption of a diet high in red meat increased DSS-induced colitis as evidenced by higher disease activity and histopathological scores. Addition of RS to the red meat diet exerted a beneficial effect in acute DSS-induced colitis. Subjective analysis of numbers of a range of bacterial targets suggest changes in the gut microbiota abundance were induced by red meat and RS treatments and these changes could contribute to the reported outcomes. CONCLUSIONS: A dietary intake of red meat aggravates DSS-induced colitis whereas co-consumption of resistant starch reduces the severity of colitis.
Keywords: Inflammation; resistant starch; red meat; gut microbiota; dextran sulfate sodium
Description: Published online: 29 August 2013
Rights: © Springer Science+Business Media New York 2013
RMID: 0030072213
DOI: 10.1007/s10620-013-2844-1
Grant ID: http://purl.org/au-research/grants/nhmrc/535079
Appears in Collections:Medicine publications

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