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https://hdl.handle.net/2440/106820
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dc.contributor.author | Le Leu, R. | - |
dc.contributor.author | Young, G. | - |
dc.contributor.author | Hu, Y. | - |
dc.contributor.author | Winter, J. | - |
dc.contributor.author | Conlon, M. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Digestive Diseases and Sciences, 2013; 58(12):3475-3482 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | http://hdl.handle.net/2440/106820 | - |
dc.description | Published online: 29 August 2013 | - |
dc.description.abstract | BACKGROUND: Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease. AIMS: The aim of this study was to determine the effects of feeding a red meat diet with and without resistant starch (RS) to mice with dextran sulfate sodium (DSS)-induced colitis. METHODS: Colonic experimental colitis was induced in Balb/c mice using DSS. The severity of colitis was evaluated based on a disease activity index (based on bodyweight loss, stool consistency, rectal bleeding, and overall condition of the animal) and a histological score. Estimations were made of numbers of a range of different bacteria in the treatment pools of cecal digesta using quantitative real-time PCR. RESULTS: Consumption of a diet high in red meat increased DSS-induced colitis as evidenced by higher disease activity and histopathological scores. Addition of RS to the red meat diet exerted a beneficial effect in acute DSS-induced colitis. Subjective analysis of numbers of a range of bacterial targets suggest changes in the gut microbiota abundance were induced by red meat and RS treatments and these changes could contribute to the reported outcomes. CONCLUSIONS: A dietary intake of red meat aggravates DSS-induced colitis whereas co-consumption of resistant starch reduces the severity of colitis. | - |
dc.description.statementofresponsibility | Richard K. Le Leu, Graeme P. Young, Ying Hu, Jean Winter, Michael A. Conlon | - |
dc.language.iso | en | - |
dc.publisher | Springer US | - |
dc.rights | © Springer Science+Business Media New York 2013 | - |
dc.source.uri | http://dx.doi.org/10.1007/s10620-013-2844-1 | - |
dc.subject | Inflammation; resistant starch; red meat; gut microbiota; dextran sulfate sodium | - |
dc.title | Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10620-013-2844-1 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/535079 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Le Leu, R. [0000-0003-4704-4943] | - |
dc.identifier.orcid | Winter, J. [0000-0002-2041-8602] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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