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Type: Journal article
Title: Spreading depression: evidence of five electroencephalogram phases
Author: Broberg, M.
Pope, K.
Olsson, T.
Shuttleworth, C.
Willoughby, J.
Citation: Journal of Neuroscience Research, 2014; 92(10):1384-1394
Publisher: John Wiley & Sons
Issue Date: 2014
ISSN: 0360-4012
Statement of
Marita Broberg, Kenneth J. Pope, Torsten Olsson, C. William Shuttleworth, and John O. Willoughby
Abstract: Spreading depression (SD), a self-propagating wave of astroglial and neuronal depolarization, is an accompaniment of several neurological disorders including epilepsy. Its well-described features are initial depolarization, followed by EEG flattening. In this in vivo study in awake animals, the relationship of SDs to epileptiform activity was re-examined. We assessed SDs generated by mechanical stimulation and by metabolic inhibition with fluorocitrate. In addition to identifying prolonged EEG depression, we identified two periods, one prior to and another during depression, characterized by increases in power of specific frequencies that were sometimes associated with epileptiform discharges. The first period was characterized by ripple activity close to the induction site (88% of SDs with intracortical electrodes). The second period was characterized by localized low-frequency spikes (100% with dural screw electrodes, 65% with intracortical electrodes). By using fluorocitrate to induce SDs, the initial period was also characterized by runs of spikes (52%). Finally, with SDs induced by both methods, there was a period at the end of depression when additional, unprovoked SDs occurred (20%). Five stages of SD were defined by these phenomena, in the order: excitation, depression, excitation, depression, SD, with metabolic inhibition enhancing the expression of epileptiform spiking.
Keywords: High-frequency activity; ripples; impedance; epileptiform discharges; fluorocitrate
Description: Published online 20 May 2014
Rights: © 2014 Wiley Periodicals, Inc.
DOI: 10.1002/jnr.23412
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Molecular and Biomedical Science publications

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