Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/10687
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Type: Journal article
Title: CD1a in human cancers: a new role for an old molecule
Author: Coventry, B.
Heinzel, S.
Citation: Trends in Immunology, 2004; 25(5):242-248
Publisher: Elsevier Sci Ltd
Issue Date: 2004
ISSN: 1471-4906
1471-4981
Statement of
Responsibility: 
Brendon Coventry and Susanne Heinzel
Abstract: CD1a is often used as marker for dendritic cells (DCs) in vitro and in vivo. The density of CD1a+ DCs within human tumours has been associated with survival. The functions of CD1a and the other members of the CD1 family have long been unclear but in recent years it has emerged that CD1 molecules present non-peptide antigens to T cells. Many of the antigens presented by CD1 molecules have been identified as glycolipids. Because many tumour-specific glycolipids are known to be immunogenic, we hypothesize that these tumour-specific glycolipids can also be presented by CD1a to T cells, and induce CD1a-restricted tumour-specific T-cell responses. Modulation of CD1a expression on tumour-infiltrating DCs is discussed in this context.
Keywords: Dendritic Cells
T-Lymphocytes
Lymphocytes, Tumor-Infiltrating
Humans
Neoplasms
Glycolipids
Gangliosides
Antigens, CD1
Antigens, Neoplasm
Survival Analysis
Antigen Presentation
Gene Expression Regulation
Models, Immunological
DOI: 10.1016/j.it.2004.03.002
Appears in Collections:Aurora harvest 7
Surgery publications

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