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Type: Journal article
Title: Stable ultrathin-shell double emulsions for controlled release
Author: Zhao, C.
Chen, D.
Hui, Y.
Weitz, D.
Middelberg, A.
Citation: ChemPhysChem: a European journal of chemical physics and physical chemistry, 2016; 17(11):1553-1556
Publisher: John Wiley & Sons
Issue Date: 2016
ISSN: 1439-4235
Statement of
Chun-Xia Zhao, Dong Chen, Yue Hui, David A. Weitz, and Anton P. J. Middelberg
Abstract: Double emulsions are normally considered as metastable systems and this limit in stability restricts their applications. To enhance their stability, the outer shell can be converted into a mechanically strong layer, for example, a polymeric layer, thus allowing improved performance. This conversion can be problematic for food and drug applications, as a toxic solvent is needed to dissolve the polymer in the middle phase and a high temperature is required to remove the solvent. This process can also be highly complex, for example, involving UV initiation of polymeric monomer crosslinking. In this study, we report the formation of biocompatible, water-in-oil-in-water (W/O/W) double emulsions with an ultrathin layer of fish oil. We demonstrate their application for the encapsulation and controlled release of small hydrophilic molecules. Without a trigger, the double emulsions remained stable for months, and the release of small molecules was extremely slow. In contrast, rapid release was achieved by osmolarity shock, leading to complete release within 2 h. This work demonstrates the significant potential of double emulsions, and provides new insights into their stability and practical applications.
Keywords: Double emulsions; encapsulation; interfaces; microreactors; surface chemistry
Rights: © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/cphc.201600142
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