Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107064
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Type: Journal article
Title: Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults
Author: Amarasekera, A.
Assadi-Khansari, B.
Liu, S.
Black, M.
Dymmott, G.
Rogers, N.
Sverdlov, A.
Horowitz, J.
Ngo, D.
Citation: PLoS ONE, 2017; 12(5):e0174435-1-e0174435-14
Publisher: Public Library of Science
Issue Date: 2017
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Anjalee T. Amarasekera, Bahador Assadi-Khansari, Saifei Liu, Marilyn Black, Greer Dymmott, Natasha M. Rogers, Aaron L. Sverdlov, John D. Horowitz, Doan T. M. Ngo
Abstract: Introduction: Vitamin D insufficiency, defined as 25-hydroxyvitamin D (25(OH)D) levels < 75nmol/L is associated with cardio-metabolic dysfunction. Vitamin D insufficiency is associated with inflammation and fibrosis, but it remains uncertain whether these anomalies are readily reversible. Therefore, we aimed to determine the effects of vitamin D supplementation on markers of: 1) nitric oxide (NO) signaling, 2) inflammation, and 3) fibrosis, in healthy volunteers with mild hypovitaminosis. Methods: Healthy volunteers (n = 35) (mean age: 45 ± 11 years) with 25(OH)D levels <75nmol/L, received vitamin D supplementation (Ostelin ® capsules 2000IU) for 12 weeks. Resting systolic and diastolic blood pressures (BP) were assessed. Routine biochemistry was examined. Plasma concentrations of asymmetric dimethylarginine (ADMA), thrombospondin-1 (TSP-1), plasminogen activator inhibitor-1 (PAI-1), hs-CRP, activin-A, and follistatin-like 3 (FSTL3) were quantitated. Results: Vitamin D administration for 12 weeks significantly increased 25-(OH)D levels (48.8 ± 16 nmol/L to 100.8 ± 23.7 nmol/L, p<0.001). There was significant lowering of systolic and diastolic BP, while there was no significant change in lipid profiles, or fasting insulin. Plasma concentrations of ADMA, hs-CRP, PAI-1, activin A, and FSTL-3 did not change with vitamin D supplementation. However, there was a marked reduction of TSP-1 (522.7 ± 379.8 ng/mL vs 206.7 ± 204.5 ng/mL, p<0.001). Conclusions: Vitamin D supplementation in vitamin D insufficient, but otherwise healthy individuals markedly decreased TSP-1 levels and blood pressure. Since TSP-1 suppresses signaling of NO, it is possible that the fall in BP is engendered by restoration of NO effect.
Keywords: Humans; Vitamin D; Thrombospondin 1; Blood Pressure; Adult; Middle Aged; South Australia; Female; Male; Healthy Volunteers
Rights: © 2017 Amarasekera et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030069710
DOI: 10.1371/journal.pone.0174435
Appears in Collections:Medicine publications

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