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Type: Journal article
Title: A novel recombinant canine adenovirus type 1 detected from acute lethal cases of infectious canine hepatitis
Author: Wong, M.
Woolford, L.
Hasan, N.
Hemmatzadeh, F.
Citation: Viral Immunology, 2017; 30(4):258-263
Publisher: Mary Ann Liebert
Issue Date: 2017
ISSN: 0882-8245
Statement of
Magdelene Wong, Lucy Woolford, Noor Haliza Hasan and Farhid Hemmatzadeh
Abstract: In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centrilobular to panlobular necrohemorrhagic hepatitis and the development of disseminated intravascular coagulation in the terminal stages of disease. Comparison of partial genome sequences revealed that although these newly detected viruses mainly had CAdV-1 genome characteristics, their pVIII gene was more similar to that of CAdV-2. This likely suggests that a recombination has occurred between CAdV-1 and CAdV-2, which possibly explains the cause of vaccine failure or increased virulence of the virus in the observed ICH cases.
Keywords: acute infections; canine adenovirus; pathogenesis; recombination; vaccines; veterinary
Rights: © Mary Ann Liebert, Inc.
RMID: 0030068746
DOI: 10.1089/vim.2016.0041
Appears in Collections:Paediatrics publications

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