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dc.contributor.authorWong, M.en
dc.contributor.authorWoolford, L.en
dc.contributor.authorHasan, N.en
dc.contributor.authorHemmatzadeh, F.en
dc.identifier.citationViral Immunology, 2017; 30(4):258-263en
dc.description.abstractIn this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centrilobular to panlobular necrohemorrhagic hepatitis and the development of disseminated intravascular coagulation in the terminal stages of disease. Comparison of partial genome sequences revealed that although these newly detected viruses mainly had CAdV-1 genome characteristics, their pVIII gene was more similar to that of CAdV-2. This likely suggests that a recombination has occurred between CAdV-1 and CAdV-2, which possibly explains the cause of vaccine failure or increased virulence of the virus in the observed ICH cases.en
dc.description.statementofresponsibilityMagdelene Wong, Lucy Woolford, Noor Haliza Hasan and Farhid Hemmatzadehen
dc.publisherMary Ann Lieberten
dc.rights© Mary Ann Liebert, Inc.en
dc.subjectacute infections; canine adenovirus; pathogenesis; recombination; vaccines; veterinaryen
dc.titleA novel recombinant canine adenovirus type 1 detected from acute lethal cases of infectious canine hepatitisen
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidWoolford, L. [0000-0001-7271-2937]en
dc.identifier.orcidHemmatzadeh, F. [0000-0002-4572-8869]en
Appears in Collections:Paediatrics publications

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