Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107114
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Aminoacyl-transfer RNA synthetase deficiency promotes angiogenesis via the unfolded protein response pathway
Author: Castranova, D.
Davis, A.
Lo, B.
Miller, M.
Paukstelis, P.
Swift, M.
Pham, V.
Torres-Vazquez, J.
Bell, K.
Shaw, K.
Kamei, M.
Weinstein, B.
Citation: Arteriosclerosis, Thrombosis, and Vascular Biology, 2016; 36(4):655-662
Publisher: Lippincott Williams & Wilkins Ltd.
Issue Date: 2016
ISSN: 1524-4636
1524-4636
Statement of
Responsibility: 
Daniel Castranova, Andrew E. Davis, Brigid D. Lo, Mayumi F. Miller, Paul J. Paukstelis, Matthew R. Swift, Van N. Pham, Jesús Torres-Vázquez, Kameha Bell, Kenna M. Shaw, Makoto Kamei, Brant M. Weinstein
Abstract: Objective—Understanding the mechanisms regulating normal and pathological angiogenesis is of great scientific and clinical interest. In this report, we show that mutations in 2 different aminoacyl-transfer RNA synthetases, threonyl tRNA synthetase (tarsy58) or isoleucyl tRNA synthetase (iarsy68), lead to similar increased branching angiogenesis in developing zebrafish. Approach and Results—The unfolded protein response pathway is activated by aminoacyl-transfer RNA synthetase deficiencies, and we show that unfolded protein response genes atf4, atf6, and xbp1, as well as the key proangiogenic ligand vascular endothelial growth factor (vegfaa), are all upregulated in tarsy58 and iarsy68 mutants. Finally, we show that the protein kinase RNA-like endoplasmic reticulum kinase–activating transcription factor 4 arm of the unfolded protein response pathway is necessary for both the elevated vegfaa levels and increased angiogenesis observed in tarsy58 mutants. Conclusions—Our results suggest that endoplasmic reticulum stress acts as a proangiogenic signal via unfolded protein response pathway–dependent upregulation of vegfaa.
Keywords: Endoplasmic reticulum; pathologic neovascularization; protein kinases; unfolded protein response; vascular endothelial growth factor A; zebrafish
Rights: © 2016 American Heart Association, Inc.
RMID: 0030046984
DOI: 10.1161/ATVBAHA.115.307087
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.