Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107155
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Type: Journal article
Title: Aspergillus felis sp. nov., an emerging agent of invasive aspergillosis in humans, cats, and dogs
Author: Barrs, V.
van Doorn, T.
Houbraken, J.
Kidd, S.
Martin, P.
Pinheiro, M.
Richardson, M.
Varga, J.
Samson, R.
Citation: PLoS ONE, 2013; 8(6):e64871-1-e64871-11
Publisher: Public Library of Science (PLoS)
Issue Date: 2013
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Vanessa R. Barrs, Tineke M. van Doorn, Jos Houbraken, Sarah E. Kidd, Patricia Martin, Maria Dolores Pinheiro, Malcolm Richardson, Janos Varga, Robert A. Samson
Abstract: We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro.
Keywords: Aspergillosis
Description: Published June 14, 2013
Rights: Copyright: © 2013 Barrs et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030058145
DOI: 10.1371/journal.pone.0064871
Appears in Collections:Molecular and Biomedical Science publications

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