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|Title:||Detection of the canine parvovirus 2c subtype in Australian dogs|
|Citation:||Viral Immunology, 2017; 30(5):371-376|
|Publisher:||Mary Ann Liebert|
|Lucy Woolford, Paul Crocker, Hannah Bobrowski, Trevor Baker, and Farhid Hemmatzadeh|
|Abstract:||Canine parvovirus (CPV-2) is an important cause of hemorrhagic enteritis in dogs. In Australia the disease has been associated with CPV-2a and CPV-2b variants. A third more recently emerged variant overseas, CPV-2c, has not been detected in surveys of the Australian dog population. In this study, we report three cases of canine parvoviral enteritis associated with CPV-2c infection; case 1 occurred in an 8-week-old puppy that died following acute hemorrhagic enteritis. Cases 2 and 3 were an 11-month-old female entire Saint Bernard and a 9-month-old male entire Siberian husky, respectively, both which had completed vaccination schedules and presented with vomiting or mild diarrhea only. Full genomic sequencing of parvoviral DNA from cases 1, 2, and 3 revealed greater than 99% homology to known CPV-2c variants and predicted protein sequences from the VP2 region of viral DNA from all three cases identified; glutamic acid residues at the 426 amino acid residue, characteristic of the CPV-2c variant. Veterinary professionals should be aware that CPV-2c is now present in Australia, detected in a puppy and vaccinated young adult dogs in this study. Further characterization of CPV-2c-associated disease and its prevalence in Australian dogs requires additional research.|
|Keywords:||canine parvovirus 2c; vaccine failure; full genome sequencing|
|Rights:||© Mary Ann Liebert, Inc.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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