Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107353
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Type: Journal article
Title: Supplementation with omega-3 fish oil has no effect on bone mineral density in adults with knee osteoarthritis: a 2-year randomized controlled trial
Author: Chen, J.
Hill, C.
Lester, S.
Ruediger, C.
Battersby, R.
Jones, G.
Cleland, L.
March, L.
Citation: Osteoporosis International, 2016; 27(5):1897-1905
Publisher: Springer London
Issue Date: 2016
ISSN: 0937-941X
1433-2965
Statement of
Responsibility: 
J. S. Chen, C. L. Hill, S. Lester, C. D. Ruediger, R. Battersby, G. Jones, L. G. Cleland, L. M. March
Abstract: This study aimed to determine the effect of fish oil on bone mineral density (BMD). There were no differences in the 2-year BMD measures between high and low dose groups after adjusting for baseline BMD. This randomized controlled trial did not demonstrate any efficacy of omega-3 fatty acids on bone loss in adults.The purpose of this study is to investigate whether supplementation with high dose omega-3 fish oil could have an impact on BMD.In a multicentre, double-blind randomized controlled trial (RCT) (ACTRN 12607000415404), 202 Australian participants aged ≥40 with knee osteoarthritis (mean age, 61.0 ± 10.0 years; 49 % female) were randomized to receive either high dose (4.5 g eicosapentaenoic acid and docosahexaenoic acid daily) or low dose (0.45 g/day) omega-3 fish oil for 2 years. BMD was assessed at baseline and 2 years by dual energy X-ray absorptiometry.In subjects with baseline and 2-year assessments, mean standardized BMD at baseline for low or high dose group was 1198 ± 198 and 1157 ± 169 mg/cm(2), respectively, for the lumbar spine and was 1035 ± 165 and 1017 ± 174 mg/cm(2), respectively, for the femoral neck. There were no differences in the 2-year BMD measures between high and low dose groups after adjusting for baseline BMD in the complete case regression analyses (lumbar spine 3.7, 95 % confidence interval (CI) -7.9 to 15.3 mg/cm(2) and femoral neck -5.5, 95 % CI -14.9 to 3.9 mg/cm(2)). The findings did not change with additional adjustments of age, gender, study centre and uses of bone-related drugs during the study period as well as using the intention-to-treat analysis or limiting to older participants (≥55 years at the baseline) (all P ≥ 0.25). Mild adverse events such as headache and gastrointestinal intolerance were common but did not occur more frequently in either group. There were no serious adverse events related to the intervention.A 2-year supplementation with high-dose omega-3 fish oil did not alter bone loss among men and women with knee osteoarthritis.
Keywords: Bone mineral density; docosahexaenoic acid; eicosapentaenoic acid; omega-3 fatty acids; randomized controlled trial
Description: Published online: 22 December 2015
Rights: © International Osteoporosis Foundation and National Osteoporosis Foundation 2015
RMID: 0030042200
DOI: 10.1007/s00198-015-3438-x
Grant ID: http://purl.org/au-research/grants/nhmrc/451900
Appears in Collections:Medicine publications

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