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Type: Journal article
Title: Maternal smoking during pregnancy and offspring trajectories of height and adiposity: comparing maternal and paternal associations
Author: Howe, L.
Matijasevich, A.
Tilling, K.
Brion, M.
Leary, S.
Smith, G.
Lawlor, D.
Citation: International Journal of Epidemiology, 2012; 41(3):722-732
Publisher: Oxford University Press
Issue Date: 2012
ISSN: 0300-5771
Statement of
Laura D Howe, Alicia Matijasevich, Kate Tilling, Marie-Jo Brion, Sam D Leary, George Davey Smith and Debbie A Lawlor
Abstract: Background; Maternal smoking during pregnancy is associated with reduced offspring birth length and has been postulated as a risk factor for obesity. Causality for obesity is not established. Causality is well-supported for birth length, but evidence on persistence of height deficits is inconsistent. Methods: We examined the association between maternal smoking during pregnancy and trajectories of offspring height (0-10 years, N = 9424), ponderal index (PI) (0-2 years, N = 9321) and body mass index (BMI) (2-10 years, N = 8887) in the Avon Longitudinal Study of Parents and Children. To strengthen inference, measured confounders were controlled for, maternal and partner smoking associations were compared, dose-response and associations with post-natal smoking were examined. Results: Maternal smoking during pregnancy was associated with shorter birth length, faster height growth in infancy and slower growth in later childhood. By 10 years, daughters of women who smoke during pregnancy are on average 1.11 cm (SE = 0.27) shorter after adjustment for confounders and partner smoking; the difference is 0.22 cm (SE = 0.22) for partner's smoking. Maternal smoking was associated with lower PI at birth, faster PI increase in infancy, but not with BMI changes 2-10 years. Associations were stronger for maternal than partner smoking for PI at birth and PI changes in infancy, but not for BMI changes after 2 years. A similar dose-response in both maternal and partner smoking was seen for BMI change 2-10 years. Conclusion: Maternal smoking during pregnancy has an intrauterine effect on birth length, and possibly on adiposity at birth and changes in height and adiposity in infancy. We do not find evidence of a specific intrauterine effect on height or adiposity changes after the age of 2 years.
Keywords: Smoking; growth; obesity; pregnancy; child; ALSPAC
Rights: © The Author 2012; all rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Published by Oxford University Press on behalf of the International Epidemiological Association
DOI: 10.1093/ije/dys025
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