Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/107493
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSautenet, B.-
dc.contributor.authorTong, A.-
dc.contributor.authorManera, K.-
dc.contributor.authorChapman, J.-
dc.contributor.authorWarrens, A.-
dc.contributor.authorRosenbloom, D.-
dc.contributor.authorWong, G.-
dc.contributor.authorGill, J.-
dc.contributor.authorBudde, K.-
dc.contributor.authorRostaing, L.-
dc.contributor.authorMarson, L.-
dc.contributor.authorJosephson, M.-
dc.contributor.authorReese, P.-
dc.contributor.authorPruett, T.-
dc.contributor.authorHanson, C.-
dc.contributor.authorO'Donoghue, D.-
dc.contributor.authorTam-Tham, H.-
dc.contributor.authorHalimi, J.-
dc.contributor.authorShen, J.-
dc.contributor.authorKanellis, J.-
dc.contributor.authoret al.-
dc.date.issued2017-
dc.identifier.citationTransplantation, 2017; 101(8):1875-1886-
dc.identifier.issn0041-1337-
dc.identifier.issn1534-6080-
dc.identifier.urihttp://hdl.handle.net/2440/107493-
dc.description.abstractBackground. Inconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals. Methods. In a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments.During rounds 2 and 3, participants rerated the outcomes after reviewing their own score, the distribution of the respondents' scores, and comments. We calculated the median, mean, and proportion rating 7 to 9 (critically important), and analyzed comments thematically. Results. One thousand eighteen participants (461 [45%] patients/caregivers and 557 [55%] health professionals) from 79 countries completed round 1, and 779 (77%) completed round 3. The top 8 outcomes that met the consensus criteria in round 3 (mean, ≥7.5; median, ≥8; proportion, >85%) in both groups were graft loss, graft function, chronic rejection, acute rejection, mortality, infection, cancer (excluding skin), and cardiovascular disease. Compared with health professionals, patients/caregivers gave higher priority to 6 outcomes (mean difference of 0.5 or more): skin cancer, surgical complications, cognition, blood pressure, depression, and ability to work. We identified 5 themes: capacity to control and inevitability, personal relevance, debilitating repercussions, gaining awareness of risks, and addressing knowledge gaps. Conclusions. Graft complications and severe comorbidities were critically important for both stakeholder groups. These stakeholderprioritized outcomes will inform the core outcome set to improve the consistency and relevance of trials in kidney transplantation.-
dc.description.statementofresponsibilityBénédicte Sautenet ... Shilpa Jesudason ... Stephen P. McDonald ... et al.-
dc.language.isoen-
dc.publisherLippincott Williams & Wilkins-
dc.rightsCopyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.-
dc.source.urihttp://dx.doi.org/10.1097/tp.0000000000001776-
dc.subjectHumans-
dc.subjectKidney Transplantation-
dc.subjectConsensus-
dc.subjectDelphi Technique-
dc.subjectAdolescent-
dc.subjectAdult-
dc.subjectAged-
dc.subjectMiddle Aged-
dc.subjectCaregivers-
dc.subjectHealth Personnel-
dc.subjectClinical Trials as Topic-
dc.subjectYoung Adult-
dc.subjectSurveys and Questionnaires-
dc.subjectOutcome Assessment, Health Care-
dc.titleDeveloping consensus-based priority outcome domains for trials in kidney transplantation: a multinational Delphi Survey with patients, caregivers, and health professionals-
dc.typeJournal article-
dc.identifier.doi10.1097/TP.0000000000001776-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1128564-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1092957-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1106716-
pubs.publication-statusPublished-
dc.identifier.orcidJesudason, S. [0000-0001-9695-0761]-
dc.identifier.orcidMcDonald, S. [0000-0001-6103-1386]-
Appears in Collections:Aurora harvest 3
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.