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Type: Conference paper
Title: Automatic detection of necrosis, normoxia and hypoxia in tumors from multimodal cytological images
Author: Carneiro, G.
Peng, T.
Bayer, C.
Navab, N.
Citation: Proceedings of the 2015 IEEE International Conference on Image Processing, 2015 / vol.2015-December, pp.2429-2433
Publisher: IEEE
Issue Date: 2015
Series/Report no.: IEEE International Conference on Image Processing ICIP
ISBN: 9781479983391
ISSN: 1522-4880
Conference Name: IEEE International Conference on Image Processing (ICIP) (27 Sep 2015 - 30 Sep 2015 : Quebec City, CANADA)
Statement of
Gustavo Carneiro, Tingying Peng, Christine Bayer, Nassir Navab
Abstract: The efficacy of cancer treatments (e.g., radiotherapy, chemotherapy, etc.) has been observed to critically depend on the proportion of hypoxic regions (i.e., a region deprived of adequate oxygen supply) in tumor tissue, so it is important to estimate this proportion from histological samples. Medical imaging data can be used to classify tumor tissue regions into necrotic or vital and then the vital tissue into normoxia (i.e., a region receiving a normal level of oxygen), chronic or acute hypoxia. Currently, this classification is a lengthy manual process performed using (immuno-)fluorescence (IF) and hematoxylin and eosin (HE) stained images of a histological specimen, which requires an expertise that is not widespread in clinical practice. In this paper, we propose a fully automated way to detect and classify tumor tissue regions into necrosis, normoxia, chronic hypoxia and acute hypoxia using IF and HE images from the same histological specimen. Instead of relying on any single classification methodology, we propose a principled combination of the following current state-of-the-art classifiers in the field: Adaboost, support vector machine, random forest and convolutional neural networks. Results show that on average we can successfully detect and classify more than 87% of the tumor tissue regions correctly. This automated system for estimating the proportion of chronic and acute hypoxia could provide clinicians with valuable information on assessing the efficacy of cancer treatments.
Keywords: Cytological microscopic images, multimodal classification, classifier combination
Rights: © 2015 IEEE
RMID: 0030043411
DOI: 10.1109/ICIP.2015.7351238
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Appears in Collections:Computer Science publications

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