Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/107795
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Type: Journal article
Title: Analysis of beat-to-beat blood pressure variability response to the cold pressor test in the offspring of hypertensive and normotensive parents
Author: Wu, D.
Xu, L.
Abbott, D.
Hau, W.
Ren, L.
Zhang, H.
Wong, K.
Citation: Hypertension Research, 2017; 40(6):581-589
Publisher: Japanese Society of Hypertension
Issue Date: 2017
ISSN: 0916-9636
1348-4214
Statement of
Responsibility: 
Dan Wu, Lin Xu, Derek Abbott, William Kongto Hau, Lijie Ren, Heye Zhang, and Kelvin K L Wong
Abstract: Abnormal autonomic nervous regulation has an important role in the development of hypertension. As to whether blood pressure (BP) or BP variability represents the proper characteristics for predisposition to hypertension in Chinese young adults remains controversial. We studied the properties of the indices extracted from beat-to-beat BP during a 13 min cold pressor test (CPT). In this study, 69 Chinese young adults including 34 offspring of hypertensive parents (OHPs; 25.6±2.5 years) and 35 offspring of normotensive parents (ONPs; 25.3±2.3 years) were analyzed. We assessed the differences between the two groups regarding mean beat-to-beat BP and variability indices. Beat-to-beat BP variability indices included time-domain indices and frequency-domain indices. Our results showed that the differences in beat-to-beat systolic BP and mean BP levels between the OHPs and the ONPs were statistically significant (P<0.05). Furthermore, more BP variability indices in the frequency domain were significantly different between the two groups. We concluded that BP variability was superior to BP as an index to evaluate the cardiovascular and sympathetic reactivity to the CPT. Moreover, compared with time-domain BP variability, we found more differences in frequency-domain BP variability between the two groups, thus indicating that frequency-domain BP variability may be a potential index of predisposition to hypertension.
Keywords: Beat-to-beat BP; cold pressor test; frequency domain; offspring of hypertensive parents
Rights: © 2017, Rights Managed by Nature Publishing Group
RMID: 0030064424
DOI: 10.1038/hr.2017.4
Appears in Collections:Medicine publications

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