Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/109109
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Type: Journal article
Title: Engineering of micro- to nanostructured 3D-printed drug-releasing titanium implants for enhanced osseointegration and localized delivery of anticancer drugs
Author: Maher, S.
Kaur, G.
Lima-Marques, L.
Evdokiou, A.
Losic, D.
Citation: ACS Applied Materials and Interfaces, 2017; 9(35):29562-29570
Publisher: American Chemical Society
Issue Date: 2017
ISSN: 1944-8244
1944-8252
Statement of
Responsibility: 
Shaheer Maher, Gagandeep Kaur, Luis Lima-Marques, Andreas Evdokiou and Dusan Losic
Abstract: Primary and secondary bone cancers are major causes of pathological bone fractures which are usually treated through implant fixation and chemotherapy. However, both approaches face many limitations. On one hand, implants may suffer from poor osseointegration, and their rejection results in repeated surgery, patient's suffering, and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics which are administrated systemically. In this paper, in order to address these two problems, we present a new type of localized drug-releasing titanium implants with enhanced implants' biointegration and drug release capabilities that could provide a high concentration of anticancer drugs locally to treat bone cancers. The implants are fabricated by 3D printing of Ti alloy followed by an anodization process featuring unique micro- (particles) and nanosurface (tubular arrays) topography. We successfully demonstrate their enhanced bone osseointegration and drug loading capabilities using two types of anticancer drugs, doxorubicin (DOX) and apoptosis-inducing ligand (Apo2L/TRAIL). In vitro study showed strong anticancer efficacy against cancer cells (MDA-MB-231-TXSA), confirming that these drug-releasing implants can be used for localized chemotherapy for treatment of primary and secondary bone cancers together with fracture support.
Keywords: 3D printing; anodization; bone cancer; bone implants; titania nanotubes
Rights: © 2017 American Chemical Society
RMID: 0030075265
DOI: 10.1021/acsami.7b09916
Grant ID: http://purl.org/au-research/grants/arc/DP120101680
http://purl.org/au-research/grants/arc/FT110100711
Appears in Collections:Chemical Engineering publications

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