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Type: Journal article
Title: Different stimulation frequencies alter synchronous fluctuations in motor evoked potential amplitude of intrinsic hand muscles-a TMS study
Author: Sale, M.
Rogasch, N.
Nordstrom, M.
Citation: Frontiers in Human Neuroscience, 2016; 10(MAR2016):1-9
Publisher: Frontiers
Issue Date: 2016
ISSN: 1662-5161
Statement of
Martin V. Sale, Nigel C. Rogasch and Michael A. Nordstrom
Abstract: The amplitude of motor-evoked potentials (MEPs) elicited with transcranial magnetic stimulation (TMS) varies from trial-to-trial. Synchronous oscillations in cortical neuronal excitability contribute to this variability, however it is not known how different frequencies of stimulation influence MEP variability, and whether these oscillations are rhythmic or aperiodic. We stimulated the motor cortex with TMS at different regular (i.e., rhythmic) rates, and compared this with pseudo-random (aperiodic) timing. In 18 subjects, TMS was applied at three regular frequencies (0.05 Hz, 0.2 Hz, 1 Hz) and one aperiodic frequency (mean 0.2 Hz). MEPs (n = 50) were recorded from three intrinsic hand muscles of the left hand with different functional and anatomical relations. MEP amplitude correlation was highest for the functionally related muscle pair, less for the anatomically related muscle pair and least for the functionally- and anatomically-unrelated muscle pair. MEP correlations were greatest with 1 Hz, and least for stimulation at 0.05 Hz. Corticospinal neuron synchrony is higher with shorter TMS intervals. Further, corticospinal neuron synchrony is similar irrespective of whether the stimulation is periodic or aperiodic. These findings suggest TMS frequency is a crucial consideration for studies using TMS to probe correlated activity between muscle pairs.
Keywords: Transcranial magnetic stimulation; cortical oscillations; motor-evoked potential; motor cortex; first dorsal interosseous; abductor pollicis brevis; abductor digiti minimi
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RMID: 0030075715
DOI: 10.3389/fnhum.2016.00100
Grant ID:
Appears in Collections:Psychology publications

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