Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/109222
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dc.contributor.authorGiezenaar, C.en
dc.contributor.authorTrahair, L.en
dc.contributor.authorLuscombe-Marsh, N.en
dc.contributor.authorHausken, T.en
dc.contributor.authorStandfield, S.en
dc.contributor.authorJones, K.en
dc.contributor.authorLange, K.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorChapman, I.en
dc.contributor.authorSoenen, S.en
dc.date.issued2017en
dc.identifier.citationAmerican Journal of Clinical Nutrition, 2017; 106(3):865-877en
dc.identifier.issn0002-9165en
dc.identifier.issn1938-3207en
dc.identifier.urihttp://hdl.handle.net/2440/109222-
dc.description.abstractBackground: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestinal mechanisms and whether these differ between men and women is limited. Objective: We determined the effects of whey protein on energy intake, appetite, gastric emptying, and gut hormones in healthy older men and women. Design: Eight older women and 8 older men [mean ± SEM age: 72 ± 1 y; body mass index (in kg/m2): 25 ± 1] were studied on 3 occasions in which they received protein loads of 30 g (120 kcal) or 70 g (280 kcal) or a flavored water control drink (0 kcal). At regular intervals over 180 min, appetite (visual analog scales), gastric emptying (3-dimensional ultrasonography), and blood glucose and plasma gut-hormone concentrations [insulin, glucagon, ghrelin, cholecystokinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide tyrosine tyrosine (PYY)] were measured, and ad libitum energy intake was quantified from a buffet meal (180-210 min; energy intake, appetite, and gastric emptying in the men have been published previously). Results: Energy intake at the buffet meal was ∼80% higher in older men than in older women (P < 0.001). Energy intake was not suppressed by protein compared with the control in men or women (P > 0.05). There was no effect of sex on gastric emptying, appetite, gastrointestinal symptoms, glucose, or gut hormones (P > 0.05). There was a protein load-dependent slowing of gastric emptying, an increase in concentrations of insulin, glucagon, cholecystokinin, GIP, GLP-1, and PYY, and an increase in total energy intake (drink plus meal: 12% increase with 30 g and 32% increase with 70 g; P < 0.001). Energy intake at the buffet meal was inversely related to the stomach volume and area under the curve of hormone concentrations (P < 0.05). Conclusion: In older men and women, whey-protein drinks load-dependently slow gastric emptying and alter gut hormone secretion compared with a control but have no suppressive effect on subsequent ad libitum energy intake. This trial was registered at www.anzctr.org.au as ACTRN12612000941864.en
dc.description.statementofresponsibilityCaroline Giezenaar, Laurence G Trahair, Natalie D Luscombe-Marsh, Trygve Hausken, Scott Standfield, Karen L Jones, Kylie Lange, Michael Horowitz, Ian Chapman, and Stijn Soenenen
dc.language.isoenen
dc.publisherAmerican Society for Clinical Nutritionen
dc.rights© 2017 American Society for Nutritionen
dc.subjectAging; appetite and energy intake; gastrointestinal function; gastrointestinal mechanisms; sex; Whey Proteinen
dc.titleEffects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and womenen
dc.typeJournal articleen
dc.identifier.rmid0030073359en
dc.identifier.doi10.3945/ajcn.117.154377en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627118en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627011en
dc.identifier.pubid365472-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS08en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGiezenaar, C. [0000-0001-5612-1918]en
dc.identifier.orcidLuscombe-Marsh, N. [0000-0001-9690-4722]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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