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Type: Journal article
Title: Tobacco control policies and perinatal health: a national quasi-experimental study
Author: Peelen, M.
Sheikh, A.
Kok, M.
Hajenius, P.
Zimmermann, L.
Kramer, B.
Hukkelhoven, C.
Reiss, I.
Mol, B.
Been, J.
Citation: Scientific Reports, 2016; 6(1):23907-1-23907-10
Publisher: Nature Publishing Group
Issue Date: 2016
ISSN: 2045-2322
Statement of
Myrthe J Peelen, Aziz Sheikh, Marjolein Kok, Petra Hajenius, Luc J Zimmermann, Boris W Kramer, Chantal W Hukkelhoven, Irwin K Reiss, Ben W Mol, Jasper V Been
Abstract: We investigated whether changes in perinatal outcomes occurred following introduction of key tobacco control policies in the Netherlands: smoke-free legislation in workplaces plus a tobacco tax increase and mass media campaign (January-February 2004); and extension of the smoke-free law to the hospitality industry, accompanied by another tax increase and mass media campaign (July 2008). This was a national quasi-experimental study using Netherlands Perinatal Registry data (2000-2011; registration: NCT02189265). Primary outcome measures were: perinatal mortality, preterm birth, and being small-for-gestational age (SGA). The association with timing of the tobacco control policies was investigated using interrupted time series logistic regression analyses with adjustment for confounders. Among 2,069,695 singleton births, there were 13,027 (0.6%) perinatal deaths, 116,043 (5.6%) preterm live-births and 187,966 (9.1%) SGA live-births. The 2004 policies were not associated with significant changes in the odds of developing any of the primary outcomes. After the 2008 policy change, a -4.4% (95% CI -2.4; -6.4, p < 0.001) decrease in odds of being SGA was observed. A reduction in SGA births, but not preterm birth or perinatal mortality, was observed in the Netherlands after extension of the smoke-free workplace law to bars and restaurants in conjunction with a tax increase and mass media campaign.
Keywords: Humans; Premature Birth; Perinatal Care; Registries; Logistic Models; Odds Ratio; Pregnancy; Databases, Factual; Infant, Newborn; Infant, Small for Gestational Age; Workplace; Taxes; Netherlands; Female; Perinatal Mortality; Non-Randomized Controlled Trials as Topic; Smoking Prevention
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
RMID: 0030046852
DOI: 10.1038/srep23907
Appears in Collections:Medicine publications

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