Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/109837
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Comparison of protective immune responses to apicomplexan parasites |
Author: | Frölich, S. Entzeroth, R. Wallach, M. |
Citation: | Journal of Parasitology Research, 2012; 2012:852591-1-852591-11 |
Publisher: | Hindawi Publishing Corporation |
Issue Date: | 2012 |
ISSN: | 2090-0023 2090-0031 |
Statement of Responsibility: | Sonja Frölich, Rolf Entzeroth and Michael Wallach |
Abstract: | Members of the phylum Apicomplexa, which includes the species Plasmodium, Eimeria, Toxoplasma, and Babesia amongst others, are the most successful intracellular pathogens known to humankind. The widespread acquisition of antimicrobial resistance to most drugs used to date has sparked a great deal of research and commercial interest in the development of vaccines as alternative control strategies. A few antigens from the asexual and sexual stages of apicomplexan development have been identified and their genes characterised; however, the fine cellular and molecular details of the effector mechanisms crucial for parasite inhibition and stimulation of protective immunity are still not entirely understood. This paper provides an overview of what is currently known about the protective immune response against the various types of apicomplexan parasites and focuses mainly on the similarities of these pathogens and their host interaction. Finally, the evolutionary relationships of these parasites and their hosts, as well as the modulation of immune functions that are critical in determining the outcome of the infection by these pathogenic organisms, are discussed. |
Rights: | Copyright © 2012 Sonja Frölich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1155/2012/852591 |
Published version: | http://dx.doi.org/10.1155/2012/852591 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_109837.pdf | Published Version | 1.76 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.