Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/109843
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Low dose of propranolol does not affect rat osteotomy healing and callus strength
Author: Smitham, P.
Crossfield, L.
Hughes, G.
Goodship, A.
Blunn, G.
Chenu, C.
Citation: Journal of Orthopaedic Research, 2014; 32(7):887-893
Publisher: Wiley
Issue Date: 2014
ISSN: 0736-0266
1554-527X
Statement of
Responsibility: 
Peter Smitham, Lawrence Crossfield, Gillian Hughes, Allen Goodship, Gordon Blunn, Chantal Chenu
Abstract: Experimental studies suggest that the β-blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone loss in rats, improves bone repair. Female Wistar rats were injected with saline or propranolol (0.1 mg/kg/day) (n = 20/group), 5 days a week for 8 weeks. Three weeks after the beginning of treatment, all rats underwent a mid-diaphyseal transverse osteotomy in the left femur. Radiographic analysis of ostetomy healing was performed 2 and 5 weeks after osteotomy. Rats were sacrificed at 5 weeks and femora collected for measurements of fracture strength by torsional testing, callus volume, and mineral content by micro-CT analysis and histology of fracture callus. Eighty nine percent of osteotomies achieved apparent radiological union by 5 weeks in both groups. Propranolol treatment did not significantly alter the torsional strength of the fractured femur compared with controls. The volume and mineralization of fracture callus at 5 weeks were not significantly different in both groups. Histology showed that endochondral ossification was not affected by propranolol. Altogether, our results demonstrate that propranolol using the regimen described does not significantly improve or inhibit rat osteotomy healing and mechanical strength.
Keywords: Propranolol; bone architecture; fracture healing; micro-CT; mechanical testing
Rights: © 2014 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc.
DOI: 10.1002/jor.22619
Published version: http://dx.doi.org/10.1002/jor.22619
Appears in Collections:Aurora harvest 3
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.