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Type: Journal article
Title: Biomolecular engineering of virus-like particles aided by computational chemistry methods
Author: Zhang, L.
Lua, L.
Middelberg, A.
Sun, Y.
Connors, N.
Citation: Chemical Society Reviews, 2015; 44(23):8608-8618
Publisher: Royal Society of Chemistry
Issue Date: 2015
ISSN: 0306-0012
Statement of
Lin Zhang, Linda H.L. Lua, Anton P. J. Middelberg, Yan Sun and Natalie K. Connors
Abstract: Virus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an appropriate physicochemical environment. VLPs can stimulate both innate and adaptive immune responses, due to their particulate structure enabling uptake by antigen presenting cells. These characteristics have led to successful development of VLP-vaccine products, and will ensure their vast potential in years to come. Future success of VLP therapeutic products will be determined by advances in their bioengineering, and also by the development of tools to design for their stability, function and application. This review focuses on approaches for VLP assembly in controlled chemical environments in vivo and in vitro, and the application of computational tools for improved chemical sequence design, and fundamental understanding of assembly.
Keywords: Virion; computational biology
Rights: This journal is ©The Royal Society of Chemistry 2015
DOI: 10.1039/c5cs00526d
Grant ID: ARC
Appears in Collections:Aurora harvest 3
Chemical Engineering publications

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