Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/110820
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: β-Cyclodextrin- and adamantyl-substituted poly(acrylate) self-assembling aqueous networks designed for controlled complexation and release of small molecules
Other Titles: beta-Cyclodextrin- and adamantyl-substituted poly(acrylate) self-assembling aqueous networks designed for controlled complexation and release of small molecules
Author: Yan, L.
Pham, D.
Clements, P.
Lincoln, S.
Wang, J.
Guo, X.
Easton, C.
Citation: Beilstein Journal of Organic Chemistry, 2017; 13:1879-1892
Publisher: Beilstein-Institut.
Issue Date: 2017
ISSN: 1860-5397
1860-5397
Statement of
Responsibility: 
Liang Yan, Duc-Truc Pham, Philip Clements, Stephen F. Lincoln, Jie Wang, Xuhong Guo and Christopher J. Easton
Abstract: Three aqueous self-assembling poly(acrylate) networks have been designed to gain insight into the factors controlling the complexation and release of small molecules within them. These networks are formed between 8.8% 6A-(2-aminoethyl)amino-6A-deoxy-6A-β-cyclodextrin, β-CDen, randomly substituted poly(acrylate), PAAβ-CDen, and one of the 3.3% 1-(2-aminoethyl)amidoadamantyl, ADen, 3.0% 1-(6-aminohexyl)amidoadamantyl, ADhn, or 2.9% 1-(12-aminododecyl)amidoadamantyl, ADddn, randomly substituted poly(acrylate)s, PAAADen, PAAADhn and PAAADddn, respectively, such that the ratio of β-CDen to adamantyl substituents is ca. 3:1. The variation of the characteristics of the complexation of the dyes methyl red, methyl orange and ethyl orange in these three networks and by β-cyclodextrin, β-CD, and PAAβ-CDen alone provides insight into the factors affecting dye complexation. The rates of release of the dyes through a dialysis membrane from the three aqueous networks show a high dependence on host-guest complexation between the β-CDen substituents and the dyes as well as the structure and the viscosity of the network as shown by ITC, 1H NMR and UV-vis spectroscopy, and rheological studies. Such networks potentially form a basis for the design of controlled drug release systems.
Keywords: Controlled release; cyclodextrin; network; poly(acrylate); self-assembly
Rights: © 2017 Yan et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030076167
DOI: 10.3762/bjoc.13.183
Grant ID: http://purl.org/au-research/grants/arc/DP110103177
Appears in Collections:Chemistry publications

Files in This Item:
File Description SizeFormat 
hdl_110820.pdfPublished Version2.47 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.