Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/110916
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Type: Journal article
Title: Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
Author: Tovar, C.
Pye, R.
Kreiss, A.
Cheng, Y.
Brown, G.
Darby, J.
Malley, R.
Siddle, H.
Skjødt, K.
Kaufman, J.
Silva, A.
Baz Morelli, A.
Papenfuss, A.
Corcoran, L.
Murphy, J.
Pearse, M.
Belov, K.
Lyons, A.
Woods, G.
Citation: Scientific Reports, 2017; 7(1):43827-1-43827-14
Publisher: Springer Nature
Issue Date: 2017
ISSN: 2045-2322
2045-2322
Statement of
Responsibility: 
Cesar Tovar, Ruth J. Pye, Alexandre Kreiss, Yuanyuan Cheng, Gabriella K. Brown, Jocelyn Darby, Roslyn C. Malley, Hannah V.T. Siddle, Karsten Skjødt, Jim Kaufman, Anabel Silva, Adriana Baz Morelli, Anthony T. Papenfuss, Lynn M. Corcoran, James M. Murphy, Martin J. Pearse, Katherine Belov, A. Bruce Lyons, Gregory M. Woods
Abstract: Devil facial tumour disease (DFTD) is a transmissible cancer devastating the Tasmanian devil (Sarcophilus harrisii) population. The cancer cell is the 'infectious' agent transmitted as an allograft by biting. Animals usually die within a few months with no evidence of antibody or immune cell responses against the DFTD allograft. This lack of anti-tumour immunity is attributed to an absence of cell surface major histocompatibility complex (MHC)-I molecule expression. While the endangerment of the devil population precludes experimentation on large experimental groups, those examined in our study indicated that immunisation and immunotherapy with DFTD cells expressing surface MHC-I corresponded with effective anti-tumour responses. Tumour engraftment did not occur in one of the five immunised Tasmanian devils, and regression followed therapy of experimentally induced DFTD tumours in three Tasmanian devils. Regression correlated with immune cell infiltration and antibody responses against DFTD cells. These data support the concept that immunisation of devils with DFTD cancer cells can successfully induce humoral responses against DFTD and trigger immune-mediated regression of established tumours. Our findings support the feasibility of a protective DFTD vaccine and ultimately the preservation of the species.
Keywords: Animals; Marsupialia; Facial Neoplasms; Histocompatibility Antigens Class I; Treatment Outcome; Immunotherapy; Immunization; Antibody Formation; Female; Male; Immunity, Humoral
Rights: © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
RMID: 0030077705
DOI: 10.1038/srep43827
Grant ID: http://purl.org/au-research/grants/arc/LP0989727
http://purl.org/au-research/grants/arc/DP130100715
http://purl.org/au-research/grants/nhmrc/1105754
http://purl.org/au-research/grants/nhmrc/1054925
http://purl.org/au-research/grants/nhmrc/9000220
http://purl.org/au-research/grants/arc/DP140103260
Appears in Collections:Medicine publications

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