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Type: Journal article
Title: Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats
Author: Johnston, I.
Tan, M.
Cao, J.
Matsos, A.
Forrest, D.
Si, E.
Fardell, J.
Hutchinson, M.
Citation: Behavioural Brain Research, 2017; 334:109-118
Publisher: Elsevier
Issue Date: 2017
ISSN: 0166-4328
Statement of
Ian N. Johnstona, Manuela Tana, Jacob Caoa, Antigone Matsosa, Daniel R.L. Forresta, Emily Sia, Joanna E. Fardella, Mark R. Hutchinsonc
Abstract: Chemotherapy can cause serious neurotoxic side effects, such as painful peripheral neuropathies and disabling cognitive impairments. Four experiments examined whether Ibudilast, a clinically approved neuroimmune therapy, would reduce tactile allodynia and memory impairments caused by oxaliplatin in laboratory rats. Rats received an intraperitoneal injection of oxaliplatin (6mg/kg i.p.) or vehicle and were assessed for tactile allodynia 3 or 5days after injection, memory impairments in the novel object and novel location recognition tests 10-12days after injection, and fear conditioning 14days after injection. Ibudilast (7.5mg/kg) or vehicle was administered prior to oxaliplatin (Experiments 1 and 3) or prior to behavioural testing (Experiments 2 and 4). Ibudilast treatment prior to oxaliplatin prevented the development of tactile allodynia and memory impairments. Ibudilast treatment prior to behavioural testing reduced oxaliplatin-induced tactile allodynia, memory impairments, and impaired renewal of fear conditioning. These results suggest that Ibudilast could be an effective treatment against oxaliplatin-induced neuropathies and cognitive impairments.
Keywords: Oxaliplatin; chemotherapy; neuropathic pain; memory impairment; ibudilast
Rights: © 2017 Elsevier B.V. All rights reserved.
RMID: 0030074420
DOI: 10.1016/j.bbr.2017.07.021
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Appears in Collections:Medicine publications

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