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https://hdl.handle.net/2440/110917
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dc.contributor.author | Johnston, I. | - |
dc.contributor.author | Tan, M. | - |
dc.contributor.author | Cao, J. | - |
dc.contributor.author | Matsos, A. | - |
dc.contributor.author | Forrest, D. | - |
dc.contributor.author | Si, E. | - |
dc.contributor.author | Fardell, J. | - |
dc.contributor.author | Hutchinson, M. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Behavioural Brain Research, 2017; 334:109-118 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.issn | 1872-7549 | - |
dc.identifier.uri | http://hdl.handle.net/2440/110917 | - |
dc.description.abstract | Chemotherapy can cause serious neurotoxic side effects, such as painful peripheral neuropathies and disabling cognitive impairments. Four experiments examined whether Ibudilast, a clinically approved neuroimmune therapy, would reduce tactile allodynia and memory impairments caused by oxaliplatin in laboratory rats. Rats received an intraperitoneal injection of oxaliplatin (6mg/kg i.p.) or vehicle and were assessed for tactile allodynia 3 or 5days after injection, memory impairments in the novel object and novel location recognition tests 10-12days after injection, and fear conditioning 14days after injection. Ibudilast (7.5mg/kg) or vehicle was administered prior to oxaliplatin (Experiments 1 and 3) or prior to behavioural testing (Experiments 2 and 4). Ibudilast treatment prior to oxaliplatin prevented the development of tactile allodynia and memory impairments. Ibudilast treatment prior to behavioural testing reduced oxaliplatin-induced tactile allodynia, memory impairments, and impaired renewal of fear conditioning. These results suggest that Ibudilast could be an effective treatment against oxaliplatin-induced neuropathies and cognitive impairments. | - |
dc.description.statementofresponsibility | Ian N. Johnstona, Manuela Tana, Jacob Caoa, Antigone Matsosa, Daniel R.L. Forresta, Emily Sia, Joanna E. Fardella, Mark R. Hutchinsonc | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2017 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bbr.2017.07.021 | - |
dc.subject | Oxaliplatin; chemotherapy; neuropathic pain; memory impairment; ibudilast | - |
dc.title | Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bbr.2017.07.021 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP110100297 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hutchinson, M. [0000-0003-2154-5950] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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