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|Title:||Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase|
|Citation:||British Heart journal, 1989; 61(2):139-143|
|Publisher:||BMJ Publishing Group|
|P A Phillips, J Sasadeus, G P Hodsman, J Horowitz, A Saltups, C I Johnston|
|Abstract:||Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.|
|Keywords:||Atrial Natriuretic Factor|
|Description:||Published Online First: 01 Sep 1989.|
|Rights:||Copyright status unknown|
|Appears in Collections:||Public Health publications|
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