Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/110989
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dc.contributor.authorKar, P.en
dc.contributor.authorJones, K.en
dc.contributor.authorPlummer, M.en
dc.contributor.authorAbdelhamid, Y.en
dc.contributor.authorGiersch, E.en
dc.contributor.authorSummers, M.en
dc.contributor.authorHatzinikolas, S.en
dc.contributor.authorHeller, S.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorDeane, A.en
dc.date.issued2017en
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2017; 102(11):3953-3960en
dc.identifier.issn0021-972Xen
dc.identifier.issn1945-7197en
dc.identifier.urihttp://hdl.handle.net/2440/110989-
dc.description.abstractContext: Acute hypoglycemia accelerates gastric emptying and increases cardiac contractility. However, antecedent hypoglycemia attenuates counterregulatory hormonal responses to subsequent hypoglycemia. Objective: To determine the effect of antecedent hypoglycemia on gastric and cardiac responses to subsequent hypoglycemia in health. Design: A prospective, single-blind, randomized, crossover study (performed at the Royal Adelaide Hospital, Adelaide, South Australia, Australia). Patients: Ten healthy young men 18 to 35 years of age were studied for 36 hours on two occasions. Interventions: Participants were randomly assigned to either antecedent hypoglycemia [three 45-minute periods of strict hypoglycemia (2.8 mmol/L] or control [three 45-minute periods of strict euglycemia (6 mmol/L)] during the initial 12-hour period. Participants were monitored overnight, and the following morning blood glucose was clamped at 2.8 mmol/L for 60 minutes and then at 6 mmol/L for 120 minutes. At least 6 weeks later participants returned for the alternative intervention. Gastric emptying and cardiac fractional shortening were measured with scintigraphy and two-dimensional echocardiography, respectively, on the morning of all 4 study days. Results: A single, acute episode of hypoglycemia accelerated gastric emptying (P = 0.01) and augmented fractional shortening (P < 0.01). Gastric emptying was unaffected by antecedent hypoglycemia (P = 0.74) whereas fractional shortening showed a trend to attenuation (P = 0.06). The adrenaline response was diminished (P < 0.05) by antecedent hypoglycemia Conclusions: In health, the acceleration of gastric emptying during hypoglycemia is unaffected by antecedent hypoglycemia, whereas the increase in cardiac contractility may be attenuated.en
dc.description.statementofresponsibilityPalash Kar, Karen L Jones, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Seva Hatzinikolas, Simon Heller, Michael Horowitz, Adam M Deaneen
dc.language.isoenen
dc.publisherThe Endocrine Societyen
dc.rights© 2017 Endocrine Societyen
dc.subjectDiabetes; pancreatic and gastrointestinal hormonesen
dc.titleAntecedent hypoglycemia does not attenuate the acceleration of gastric emptying by hypoglycemiaen
dc.typeJournal articleen
dc.identifier.rmid0030076621en
dc.identifier.doi10.1210/jc.2017-00051en
dc.identifier.pubid371726-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidDeane, A. [0000-0002-7620-5577]en
Appears in Collections:Medicine publications

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