Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111051
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort study
Author: Grzeskowiak, L.
Leggett, C.
Costi, L.
Roberts, C.
Amir, L.
Citation: British Journal of Clinical Pharmacology, 2018; 84(6):1373-1379
Publisher: Wiley/Blackwell
Issue Date: 2018
ISSN: 0306-5251
1365-2125
Statement of
Responsibility: 
Luke E Grzeskowiak, Catherine Leggett, Lynn Costi, Claire T Roberts, Lisa H Amir
Abstract: Aims: To examine the association between late pregnancy exposure to serotonin reuptake inhibitor (SRI) antidepressants and difficulties in achieving an adequate breast milk supply in women who gave birth to preterm infants, while accounting for the potential impacts of underlying maternal psychiatric illness. Methods: Retrospective cohort study of 3,024 women delivering liveborn preterm infants (<37 weeks' gestation) between January 2004 and December 2008. The primary outcome was postnatal domperidone use, considered a valid proxy for presence and pharmacological management of low milk supply. Relative risks adjusted for maternal soiodemographics and comorbidities (aRRs) were calculated for low milk supply, comparing women with late pregnancy exposure to SRI antidepressants (n = 86), women with a psychiatric illness but no antidepressant use (n = 126), and women with neither antenatal exposures (n = 2 812). Results: Compared to non-exposed women, non-medicated psychiatric illness (aRR 1.64; 95%CI 1.16-2.30) but not late pregnancy SRI use (aRR 1.00; 95%CI 0.59-1.70) was associated with an increased risk of domperidone use, indicative of low milk supply. Conclusions: These findings do not support the previously observed negative impacts of antidepressant use on breastfeeding, instead suggesting that women with an underlying psychiatric illness appear at greatest risk of experiencing low milk supply and could benefit from additional breastfeeding education and support.
Keywords: serotonin agents; antidepressive agents; breastfeeding; lactation; premature birth
Rights: © 2018 The British Pharmacological Society
RMID: 0030083685
DOI: 10.1111/bcp.13575
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.