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Type: Journal article
Title: The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
Author: Cildir, G.
Pant, H.
Lopez, A.
Tergaonkar, V.
Citation: Journal of Experimental Medicine, 2017; 214(9):2491-2506
Publisher: Rockefeller University Press
Issue Date: 2017
ISSN: 0022-1007
Statement of
Gökhan Cildir, Harshita Pant, Angel F. Lopez, Vinay Tergaonkar
Abstract: Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.
Keywords: Gene Expression Regulation
Rights: © 2017 Cildir et al. article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at
RMID: 0030078735
DOI: 10.1084/jem.20170910
Appears in Collections:Genetics publications

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