Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111180
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dc.contributor.authorHays, R.en
dc.contributor.authorThompson, F.en
dc.contributor.authorEsterman, A.en
dc.contributor.authorMcDermott, R.en
dc.date.issued2016en
dc.identifier.citationOpen Forum Infectious Diseases, 2016; 3(1):1-6en
dc.identifier.issn2328-8957en
dc.identifier.issn2328-8957en
dc.identifier.urihttp://hdl.handle.net/2440/111180-
dc.description.abstractBackground: This study examines the predictive value of eosinophilia for Strongyloides stercoralis infection, as measured by enzyme-linked immunosorbent assay (ELISA) testing, in an endemic community. In remote communities, eosinophilia is frequently used as a proxy test for the presence of helminth infections. Past studies of eosinophilia and Strongyloides infection have been conducted in specific groups such as immigrants and refugees, or in subpopulations of nonendemic communities, rather than in endemic communities. Methods: We conducted a cross-sectional study of the relationship between eosinophilia and Strongyloides ELISA serology, as part of a study into the relationship between S stercoralis infection and type 2 diabetes mellitus (T2DM) in an Indigenous community in northern Australia. Results: Two hundred thirty-nine adults had their eosinophil count and S stercoralis ELISA serology measured in 2012 and 2013, along with other biometric and metabolic data. Eosinophilia was found to have a relatively poor sensitivity (60.9%), specificity (71.1%), positive predictive value (54.6%), and negative predictive value (76.1%) for S stercoralis ELISA positivity in this group. However, there was a more constant relationship between eosinophilia and S Stercoralis ELISA positivity in patients with T2DM (negative predictive value 87.5%). Conclusion: This study suggests that the presence or absence of eosinophilia is not an adequate proxy test for S stercoralis infection in a community where the infection is prevalent, and that the association between eosinophilia and S stercoralis ELISA positivity is more constant in patients with T2DM.en
dc.description.statementofresponsibilityRussell Hays, Fintan Thompson, Adrian Esterman and Robyn McDermotten
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.en
dc.subjectEosinophilia; Strongyloides stercoralis; type 2 diabetes mellitusen
dc.titleStrongyloides stercoralis, eosinophilia, and type 2 diabetes mellitus: the predictive value of eosinophilia in the diagnosis of S stercoralis infection in an endemic communityen
dc.typeJournal articleen
dc.identifier.rmid0030080796en
dc.identifier.doi10.1093/ofid/ofw029en
dc.identifier.pubid257849-
pubs.library.collectionPublic Health publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidEsterman, A. [0000-0001-7324-9171]en
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