Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/111469
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMilne, E.-
dc.contributor.authorGreenop, K.-
dc.contributor.authorRamankutty, P.-
dc.contributor.authorMiller, M.-
dc.contributor.authorde Klerk, N.-
dc.contributor.authorArmstrong, B.-
dc.contributor.authorAlmond, T.-
dc.contributor.authorO'Callaghan, N.-
dc.contributor.authorFenech, M.-
dc.date.issued2015-
dc.identifier.citationMolecular Nutrition and Food Research, 2015; 59(10):2057-2065-
dc.identifier.issn1613-4125-
dc.identifier.issn1613-4133-
dc.identifier.urihttp://hdl.handle.net/2440/111469-
dc.description.abstractScope:Maintenance of normal cellular phenotype depends largely on accurate DNA replication and repair. DNA damage causes gene mutations and predisposes to cancer and other chronic diseases. Growing evidence indicates that nutritional factors are associated with DNA damage in adults; here, we investigate these associations in children. Methods and results: We conducted a cross-sectional study among 462 healthy children 3, 6, and 9 years of age. Blood was collected and micronutrient levels were measured. The cytokinesis-block micronucleus cytome assay was used to measure chromosomal DNA damage (micronuclei, nucleoplasmic bridges, and nuclear buds) in lymphocytes. Cell apoptosis, necrosis, and the nuclear division index were also measured. Nine loci in genes involved in folate metabolism and DNA repair were genotyped. Data were analyzed using linear regression with adjustment for potential confounders. Plasma calcium was positively associated with micronuclei and necrosis, and α-tocopherol negatively associated with apoptosis, nuclear division index, and nucleoplasmic bridges; lutein was positively associated with nucleoplasmic bridges. α-tocopherol was positively associated with necrosis. Conclusion: DNA damage in healthy children may be influenced by blood micronutrient levels and certain genotypes. Further investigation of associations between nutritional status and genomic integrity in children is needed to shed additional light on potential mechanisms.-
dc.description.statementofresponsibilityElizabeth Milne, Kathryn R. Greenop, Padmaja Ramankutty, Margaret Miller, Nicholas H. de Klerk, Bruce K. Armstrong, Theodora Almond, Nathan J. O'Callaghan and Michael Fenech-
dc.language.isoen-
dc.publisherJohn Wiley & Sons-
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.source.urihttp://dx.doi.org/10.1002/mnfr.201500110-
dc.subjectChildren-
dc.subjectCytotoxicity-
dc.subjectDNA Damage-
dc.subjectMicronutrient levels-
dc.subjectMicronuclei-
dc.titleBlood micronutrients and DNA damage in children-
dc.typeJournal article-
dc.identifier.doi10.1002/mnfr.201500110-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/572623-
pubs.publication-statusPublished-
dc.identifier.orcidFenech, M. [0000-0002-8466-0991]-
Appears in Collections:Aurora harvest 8
Pharmacology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.