Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111545
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Type: Journal article
Title: Maternal circadian rhythms and the programming of adult health and disease
Author: Varcoe, T.
Gatford, K.
Kennaway, D.
Citation: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2017; 314(2):R231-R241
Publisher: American Physiological Society
Issue Date: 2017
ISSN: 0363-6119
1522-1490
Statement of
Responsibility: 
Tamara J. Varcoe, X Kathryn L. Gatford, and David J. Kennaway
Abstract: The in utero environment is inherently rhythmic, with the fetus subjected to circadian changes in temperature, substrates and various maternal hormones. Meanwhile, the fetus is developing an endogenous circadian timing system, preparing for life in an external environment where light, food availability and other environmental factors change predictably and repeatedly every 24 hours. In humans, there are many situations that can disrupt circadian rhythms, including shift work, international travel, insomnias and circadian rhythm disorders (e.g., advanced/delayed sleep phase disorder), with a growing consensus that this chronodisruption can have deleterious consequences for an individual's health and wellbeing. However, the impact of chronodisruption during pregnancy on the health of both the mother and fetus is not well understood. In this review we outline circadian timing system ontogeny in mammals, and examine emerging research from animal models demonstrating long term negative implications for progeny health following maternal chronodisruption during pregnancy.
Keywords: circadian rhythm; metabolism; pregnancy; programming
Rights: Copyright © 2018 the American Physiological Society
RMID: 0030077853
DOI: 10.1152/ajpregu.00248.2017
Grant ID: http://purl.org/au-research/grants/nhmrc/1009877
http://purl.org/au-research/grants/nhmrc/1106674
Appears in Collections:Paediatrics publications

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