Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/111591
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Type: Journal article
Title: Effect of long-term dietary sphingomyelin supplementation on atherosclerosis in mice
Author: Chung, R.
Wang, Z.
Bursill, C.
Wu, B.
Barter, P.
Rye, K.
Citation: PLoS One, 2017; 12(12):1-13
Publisher: Public Library of Science
Issue Date: 2017
ISSN: 1932-6203
1932-6203
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Responsibility: 
Rosanna W.S. Chung, Zeneng Wang, Christina A. Bursill, Ben J. Wu, Philip J. Barter, Kerry-Anne Rye
Abstract: Sphingomyelin (SM) levels in the circulation correlate positively with atherosclerosis burden. SM is a ubiquitous component of human diets, but it is unclear if dietary SM increases circulating SM levels. Dietary choline increases atherosclerosis by raising circulating trimethylamine N-oxide (TMAO) levels in mice and humans. As SM has a choline head group, we ask in this study if dietary SM accelerates atherosclerotic lesion development by increasing circulating SM and TMAO levels. Three studies were performed: (Study 1) C57BL/6 mice were maintained on a high fat diet with or without SM supplementation for 4 weeks prior to quantification of serum TMAO and SM levels; (Study 2) atherosclerosis was studied in apoE-/- mice after 16 weeks of a high fat diet without or with SM supplementation and (Study 3) apoE-/- mice were maintained on a chow diet for 19 weeks without or with SM supplementation and antibiotic treatment prior to quantification of atherosclerotic lesions and serum TMAO and SM levels. SM consumption did not increase circulating SM levels or atherosclerosis in high fat-fed apoE-/- mice. Serum TMAO levels in C57BL/6 mice were low and had no effect atherosclerosis lesion development. Dietary SM supplementation significantly reduced atherosclerotic lesion area in the aortic arch of chow-fed apoE-/- mice. This study establishes that dietary SM does not affect circulating SM levels or increase atherosclerosis in high fat-fed apoE-/- mice, but it is anti-atherogenic in chow-fed apoE-/- mice.
Keywords: Sphingomyelins; dietary supplements
Rights: © 2017 Chung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0189523
Grant ID: http://purl.org/au-research/grants/nhmrc/1037903
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