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Type: Journal article
Title: Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens
Author: Talbott, J.
Houbraken, J.
Frisvad, J.
Samson, R.
Kidd, S.
Pitt, J.
Lindsay, S.
Beatty, J.
Barrs, V.
Citation: PLoS ONE, 2017; 12(8):e0181660-1-e0181660-17
Publisher: Public Library of Science (PLoS)
Issue Date: 2017
ISSN: 1932-6203
Statement of
Jessica J. Talbot, Jos Houbraken, Jens C. Frisvad, Robert A. Samson, Sarah E. Kidd, John Pitt, Sue Lindsay, Julia A. Beatty, Vanessa R. Barrs
Abstract: Invasive fungal infections, IFI, due to species in Aspergillus section Fumigati, ASF, including the Aspergillus viridinutans species complex, AVSC, are increasingly reported in humans and cats. The risk of exposure to these medically important fungi in Australia is unknown. Air and soil was sampled from the domiciles of pet cats diagnosed with these IFI and from a nature reserve in Frankston, Victoria, where Aspergillus viridinutans sensu stricto was discovered in, . Of, ASF species isolated, were A. fumigatus sensu stricto, were AVSC, A. felis-clade and A. frankstonensis sp. nov., and, were other species, . Seven pathogenic ASF species known to cause disease in humans and animals, A. felis-clade, A. fischeri, A. thermomutatus, A. lentulus, A. laciniosus A. fumisynnematus, A. hiratsukae, comprised, of isolates overall. AVSC species were only isolated from Frankston soil where they were abundant, suggesting a particular ecological niche. Phylogenetic, morphological and metabolomic analyses of these isolates identified a new species, A. frankstonensis that is phylogenetically distinct from other AVSC species, heterothallic and produces a unique array of extrolites, including the UV spectrum characterized compounds DOLD, RAIMO and CALBO. Shared morphological and physiological characteristics with other AVSC species include slow sporulation, optimal growth at, ÊC, no growth at, ÊC, and viriditoxin production. Overall, the risk of environmental exposure to pathogenic species in ASF in Australia appears to be high, but there was no evidence of direct environmental exposure to AVSC species in areas where humans and cats cohabitate.
Keywords: Animals; Cats; Humans; Aspergillus; Aspergillosis; Naphthols; DNA, Fungal; Antifungal Agents; Microbial Sensitivity Tests; Sequence Analysis, DNA; Soil Microbiology; Environmental Exposure; Environmental Monitoring; Phylogeny; Base Sequence; Australia; Invasive Fungal Infections
Rights: Copyright: © 2017 Talbot et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030075891
DOI: 10.1371/journal.pone.0181660
Appears in Collections:Molecular and Biomedical Science publications

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