Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111647
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dc.contributor.authorErickson, A.en
dc.contributor.authorDeiteren, A.en
dc.contributor.authorHarrington, A.en
dc.contributor.authorGarcia-Caraballo, S.en
dc.contributor.authorCastro, J.en
dc.contributor.authorCaldwell, A.en
dc.contributor.authorGrundy, L.en
dc.contributor.authorBrierley, S.en
dc.date.issued2018en
dc.identifier.citationThe Journal of Physiology, 2018; 596(5):785-807en
dc.identifier.issn0022-3751en
dc.identifier.issn1469-7793en
dc.identifier.urihttp://hdl.handle.net/2440/111647-
dc.description.abstractChronic visceral pain, altered motility and bladder dysfunction are common, yet poorly managed symptoms of functional and inflammatory disorders of the gastrointestinal and urinary tracts. Recently, numerous human channelopathies of the voltage-gated sodium (NaV) channel family have been identified, which induce either painful neuropathies, an insensitivity to pain, or alterations in smooth muscle function. The identification of these disorders, in addition to the recent utilisation of genetically modified NaV mice and specific NaV channel modulators, has shed new light on how NaV channels contribute to the function of neuronal and non-neuronal tissues within the gastrointestinal tract and bladder. Here we review the current pre-clinical and clinical evidence to reveal how the nine NaV channel family members (NaV1.1–NaV1.9) contribute to abdominal visceral function in normal and disease states.en
dc.description.statementofresponsibilityAndelain Erickson, Annemie Deiteren, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Ashlee Caldwell, Luke Grundy, and Stuart M. Brierleyen
dc.language.isoenen
dc.publisherThe Physiological Societyen
dc.rights© 2018 The Authors. The Journal of Physiology C 2018 The Physiological Societyen
dc.subjectColon; bladder; sensory afferents; nociceptors; pain; inflammation; dorsal root gangliaen
dc.titleVoltage-gated sodium channels: (NaV)igating the field to determine their contribution to visceral nociceptionen
dc.typeJournal articleen
dc.identifier.rmid0030080413en
dc.identifier.doi10.1113/JP273461en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1126378en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1083480en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139366en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140297en
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180101395en
dc.identifier.pubid392067-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHarrington, A. [0000-0002-1562-4137]en
dc.identifier.orcidCastro, J. [0000-0002-5781-2224]en
dc.identifier.orcidGrundy, L. [0000-0002-3900-7141]en
dc.identifier.orcidBrierley, S. [0000-0002-2527-2905]en
Appears in Collections:Medicine publications

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