Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111686
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dc.contributor.authorNayyar, S.en
dc.contributor.authorWilson, L.en
dc.contributor.authorGanesan, A.en
dc.contributor.authorSullivan, T.en
dc.contributor.authorKuklik, P.en
dc.contributor.authorYoung, G.en
dc.contributor.authorSanders, P.en
dc.contributor.authorRoberts-Thomson, K.en
dc.date.issued2018en
dc.identifier.citationJournal of Interventional Cardiac Electrophysiology, 2018; 51(1):13-24en
dc.identifier.issn1383-875Xen
dc.identifier.issn1572-8595en
dc.identifier.urihttp://hdl.handle.net/2440/111686-
dc.description.abstractPurpose: Protected channels of surviving myocytes in late postinfarction ventricular scar predispose to ventricular tachycardia (VT). However, only a few patients develop VT spontaneously. We studied differences in electric remodeling and protected channels in late postinfarction patients with and without spontaneous VT. Methods: Patients with ischemic cardiomyopathy (ICM) with recurrent sustained monomorphic VT (n = 22) were compared with stable ICM patients without spontaneous VT (control group; n = 5). Left ventricular mapping was performed with a 20-pole catheter. Detailed pace mapping was used to identify channels of protected conduction, and confirmed, when feasible, by entrainment. Anatomical and electrophysiological properties of VT channels and non-VT channels in VT patients and channels in controls were evaluated. Results: Seventy-three (median 3) VTs were inducible in VT patients compared to two (median 0) in controls. The VT channels in VT patients (n = 57, 3 ± 1 per patient) were lengthier (mean ± SEM 53 ± 5 vs. 33 ± 4 vs. 24 ± 8 mm), had longer S-QRS (73 ± 4 vs. 63 ± 3 vs. 44 ± 8 ms), longer conduction time (103 ± 13 vs. 33 ± 4 vs. 24 ± 8 ms), and slower conduction velocity (CV) (0.85 ± 0.21 vs. 1.39 ± 0.20 vs. 1.31 ± 0.41 m/s) than non-VT channels in VT patients (n = 183, 8 ± 6 per patient) (p ≤ 0.01) and channels in controls (n = 46, 9 ± 8 per patient) (p ≤ 0.01). Additionally, non-VT channels in VT patients had longer S-QRS (p = 0.02); however, they were similar in length, conduction time, and CV compared to channels in controls. Conclusions: Channels supporting VT are lengthier, with longer conduction times and slower CV compared to channels in patients without spontaneous VT. These observations may explain why some ICM patients have spontaneous VT and others do not.en
dc.description.statementofresponsibilitySachin Nayyar, Lauren Wilson, Anand Ganesan, Thomas Sullivan, Pawel Kuklik, Glenn Young, Prashanthan Sanders, Kurt C. Roberts-Thomsonen
dc.language.isoenen
dc.publisherSpringeren
dc.rights© Springer Science+Business Media, LLC, part of Springer Nature 2017en
dc.subjectChannels; ischemic cardiomyopathy; substrate; Ventricular tachycardiaen
dc.titleElectrophysiologic features of protected channels in late postinfarction patients with and without spontaneous ventricular tachycardiaen
dc.typeJournal articleen
dc.identifier.rmid0030079422en
dc.identifier.doi10.1007/s10840-017-0299-6en
dc.identifier.pubid390692-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidKuklik, P. [0000-0001-8440-654X]en
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]en
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