Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/111725
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Christiansen, D. | - |
dc.contributor.author | Earnest-Silveira, L. | - |
dc.contributor.author | Chua, B. | - |
dc.contributor.author | Boo, I. | - |
dc.contributor.author | Drummer, H.E. | - |
dc.contributor.author | Grubor-Bauk, B. | - |
dc.contributor.author | Gowans, E.J. | - |
dc.contributor.author | Jackson, D.C. | - |
dc.contributor.author | Torresi, J. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Viral Immunology, 2018; 31(4):1-6 | - |
dc.identifier.issn | 1557-8976 | - |
dc.identifier.issn | 1557-8976 | - |
dc.identifier.uri | http://hdl.handle.net/2440/111725 | - |
dc.description.abstract | The development of an effective preventative hepatitis C virus (HCV) vaccine will reside, in part, in its ability to elicit neutralizing antibodies (NAbs). We previously reported a genotype 1a HCV virus like particle (VLP) vaccine that produced HCV specific NAb and T cell responses that were substantially enhanced by Toll-like receptor 2 (TLR2) agonists. We have now produced a quadrivalent genotype 1a/1b/2a/3a HCV VLP vaccine and tested the ability of two TLR2 agonists, R₄Pam₂Cys and E₈Pam₂Cys, to stimulate the production of NAb. We now show that our vaccine with R₄Pam₂Cys or E₈Pam₂Cys produces strong antibody and NAb responses in vaccinated mice after just two doses. Total antibody titers were higher in mice inoculated with vaccine plus E₈Pam₂Cys compared to HCV VLPs alone. However, the TLR2 agonists did not result in stronger NAb responses compared to vaccine without adjuvant. Such a vaccine could provide a substantial addition to the overall goal to eliminate HCV. | - |
dc.description.statementofresponsibility | Dale Christiansen, Linda Earnest-Silveira, Brendon Chua, Irene Boo, Heidi E. Drummer, Branka Grubor-Bauk, Eric J. Gowans, David C. Jackson, and Joseph Torresi | - |
dc.language.iso | en | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.rights | © Mary Ann Liebert, Inc. | - |
dc.source.uri | http://dx.doi.org/10.1089/vim.2017.0182 | - |
dc.subject | Hepatitis C; neutralizing antibody; virus like particles; quadrivalent vaccine | - |
dc.title | Antibody responses to a quadrivalent Hepatitis C viral-like particle vaccine adjuvanted with Toll-like receptor 2 agonists | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1089/vim.2017.0182 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1060436 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1126379 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1060433 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grubor-Bauk, B. [0000-0002-4642-105X] | - |
dc.identifier.orcid | Gowans, E.J. [0000-0002-4274-8311] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.