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Type: Journal article
Title: Three-dimensional reconstruction of peripheral nerve internal fascicular groups
Author: Zhong, Y.
Wang, L.
Dong, J.
Zhang, Y.
Luo, P.
Qi, J.
Liu, X.
Xian, C.
Citation: Scientific Reports, 2015; 5(1):17168-1-17168-13
Publisher: Nature Publishing Group
Issue Date: 2015
ISSN: 2045-2322
Statement of
Yingchun Zhong, Liping Wang, Jianghui Dong, Yi Zhang, Peng Luo, Jian Qi, Xiaolin Liu and Cory J. Xian
Abstract: Peripheral nerves are important pathways for receiving afferent sensory impulses and sending out efferent motor instructions, as carried out by sensory nerve fibers and motor nerve fibers. It has remained a great challenge to functionally reconnect nerve internal fiber bundles (or fascicles) in nerve repair. One possible solution may be to establish a 3D nerve fascicle visualization system. This study described the key technology of 3D peripheral nerve fascicle reconstruction. Firstly, fixed nerve segments were embedded with position lines, cryostat-sectioned continuously, stained and imaged histologically. Position line cross-sections were identified using a trained support vector machine method, and the coordinates of their central pixels were obtained. Then, nerve section images were registered using the bilinear method, and edges of fascicles were extracted using an improved gradient vector flow snake method. Subsequently, fascicle types were identified automatically using the multi-directional gradient and second-order gradient method. Finally, a 3D virtual model of internal fascicles was obtained after section images were processed. This technique was successfully applied for 3D reconstruction for the median nerve of the hand-wrist and cubital fossa regions and the gastrocnemius nerve. This nerve internal fascicle 3D reconstruction technology would be helpful for aiding peripheral nerve repair and virtual surgery.
Keywords: Median Nerve
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
DOI: 10.1038/srep17168
Appears in Collections:Aurora harvest 8
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