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dc.contributor.authorBoyce, S.-
dc.contributor.authorNassar, N.-
dc.contributor.authorLee, C.-
dc.contributor.authorSuen, M.-
dc.contributor.authorZahrani, S.-
dc.contributor.authorGladman, M.-
dc.identifier.citationMedical Journal of Australia, 2016; 205(10):465-470-
dc.description.abstractObjective: Australia has the highest incidence of colorectal cancer (CRC) in the world. The incidence of young-onset CRC (yCRC) is increasing in developed nations. Our aim was to determine the incidence of yCRC in New South Wales, the demographic and clinico-pathological characteristics of these patients, and their survival. Design, setting, participants: A population-based cohort study of all cases of CRC diagnosed in NSW during 2001-2008. Data on newly diagnosed cases of CRC were obtained from the NSW Central Cancer Registry; mortality data were obtained from the NSW Registry of Births Deaths and Marriages (to 2012). The characteristics and tumour-related factors of patients under 50 years of age (yCRC) were compared with those for patients aged 50 years or more. Main outcome measures: Current incidence of yCRC and trends in incidence; 5-year cancer-specific survival rates and risks of death compared with older patients. Results: 32 178 patients were diagnosed with CRC, including 2001 (6.2%) with yCRC. The incidence of yCRC was unchanged across the study period (2001, 13.7 cases per 100 000 population; 2008, 11.8 per 100 000; P = 0.26). Rectal cancer was more frequent in yCRC than in older patients (34.4% v 26.0%), as was distant disease (21.2% v 15.3%). However, 5-year cancer-specific survival was greater for patients with yCRC (68.8%; 95% CI, 66.2-71.2%) than for older patients (66.3%; 95% CI, 65.6-67.0%; P < 0.001). Conclusions: The incidence of yCRC did not increase in NSW during 2001-2008. Despite more advanced disease at presentation, cancer-specific survival was better than for older patients with CRC.-
dc.description.statementofresponsibilityStephen Boyce, Natasha Nassar, Cathy Yuen Yi Lee, Michael KL Suen, Saleh Al Zahrani, Marc A Gladman-
dc.publisherAustralasian Medical Publishing Company-
dc.rights© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved.-
dc.subjectColorectal Neoplasms-
dc.subjectMass Screening-
dc.subjectSurvival Rate-
dc.subjectMultivariate Analysis-
dc.subjectProportional Hazards Models-
dc.subjectCohort Studies-
dc.subjectAge of Onset-
dc.subjectAged, 80 and over-
dc.subjectMiddle Aged-
dc.subjectNew South Wales-
dc.subjectKaplan-Meier Estimate-
dc.titleYoung-onset colorectal cancer in New South Wales: a population-based study-
dc.typeJournal article-
dc.identifier.orcidGladman, M. [0000-0001-8412-9570]-
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