Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111803
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dc.contributor.authorMcCarron, A.en
dc.contributor.authorDonnelley, M.en
dc.contributor.authorParsons, D.en
dc.date.issued2018en
dc.identifier.citationRespiratory Research, 2018; 19(1):54-1-54-12en
dc.identifier.issn1465-9921en
dc.identifier.issn1465-993Xen
dc.identifier.urihttp://hdl.handle.net/2440/111803-
dc.description.abstractIn humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered investigations of airway disease pathogenesis, as well as the development and testing of potential therapeutics. However, recently generated CF animal models including rat, ferret and pig models demonstrate a range of well characterised lung disease phenotypes with varying degrees of severity. This review discusses the airway phenotypes of currently available CF animal models and presents potential applications of each model in airway-related CF research.en
dc.description.statementofresponsibilityAlexandra McCarron, Martin Donnelley and David Parsonsen
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectCystic fibrosis; animal models; lung disease; pathologyen
dc.titleAirway disease phenotypes in animal models of cystic fibrosisen
dc.typeJournal articleen
dc.identifier.rmid0030085008en
dc.identifier.doi10.1186/s12931-018-0750-yen
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1098127en
dc.identifier.pubid404637-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidDonnelley, M. [0000-0002-5320-7756]en
dc.identifier.orcidParsons, D. [0000-0003-1746-3290]en
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