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Type: Journal article
Title: Pain-causing venom peptides: insights into sensory neuron pharmacology
Author: Jami, S.
Erickson, A.
Brierley, S.
Vetter, I.
Citation: Toxins, 2018; 10(1):1-15
Publisher: MDPI
Issue Date: 2018
ISSN: 2072-6651
Statement of
Sina Jami, Andelain Erickson, Stuart M. Brierley and Irina Vetter
Abstract: Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or "algesic" venom compounds have proven invaluable to our understanding of how physiological nociceptive neural networks operate. In this review, we present an overview of some of the diverse nociceptive pathways that can be modulated by specific venom components to evoke pain.
Keywords: ASIC
TRP channel
animal venom
pore forming toxin
sodium channel
Rights: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/toxins10010015
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