Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/111814
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Impaired bolus clearance in asymptomatic older adults during high-resolution impedance manometry |
Author: | Cock, C. Besanko, L. Kritas, S. Burgstad, C. Thompson, A. Heddle, R. Fraser, R. Omari, T. |
Citation: | Neurogastroenterology and Motility, 2016; 28(12):1890-1901 |
Publisher: | Wiley |
Issue Date: | 2016 |
ISSN: | 1350-1925 1365-2982 |
Statement of Responsibility: | C. Cock, L. Besanko, S. Kritas, C.M. Burgstad, A. Thompson, R. Heddle, R.J.L. Fraser, T.I. OmariI |
Abstract: | Background: Dysphagia becomes more common in old age. We performed high-resolution impedance manometry (HRIM) in asymptomatic healthy adults (including an older cohort >80 years) to assess HRIM findings in relation to bolus clearance. Methods: Esophageal HRIM was performed in a sitting posture in 45 healthy volunteers (n = 30 young control, mean age 37 ± 11 years and n = 15 older subjects aged 85 ± 4 years) using a 3.2-mm solid-state catheter (Solar GI system; MMS, Enschede, The Netherlands) with 25 pressure (1-cm spacing) and 12 impedance segments (2-cm intervals). Five swallows each of 5- and 10-mL liquid and viscous bolus were performed and analyzed using esophageal pressure topography metrics and Chicago classification criteria as well as pressure-flow parameters. Bolus transit was determined using standard impedance criteria. A p-value <0.05 was considered significant. Key Results: Impaired bolus clearance occurred more frequently in asymptomatic older subjects compared with young controls (YC) during liquid (40 vs 18%, χ2 = 4.935; p < 0.05) and viscous (60 vs 17%; χ2 = 39.08; p < 0.001) swallowing. Longer peristaltic breaks (p < 0.05) and more rapid peristalsis (L: p < 0.004, V: p = 0.003) occurred in the older cohort, with reduced impedance-based clearance for both bolus consistencies (L: p < 0.05, V: p < 0.001). Decreased peristaltic vigor (distal contractile integral <450 mmHg/s/cm) was associated with reduced liquid clearance in both age groups (p < 0.001) and of viscous swallows in the older group (p < 0.001). Impedance ratio, a marker of bolus retention, was increased in older subjects during liquid (p = 0.002) and viscous (p < 0.001) swallowing. Conclusions & Inferences: Impaired liquid and viscous bolus clearance, esophageal pressure topography, and pressure-flow changes were seen in asymptomatic older subjects. |
Keywords: | Aging; bolus clearance; manometry; presbyesophagus; pressure-flow analysis |
Rights: | © 2016 John Wiley & Sons Ltd |
DOI: | 10.1111/nmo.12892 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1111/nmo.12892 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.