Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/111832
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Type: Journal article
Title: Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia
Author: Piaru, S.
Mahmud, R.
Abdul Majid, A.
Mahmoud Nassar, Z.
Citation: Asian Pacific Journal of Tropical Medicine, 2012; 5(4):294-298
Publisher: Elsevier
Issue Date: 2012
ISSN: 1995-7645
2352-4146
Statement of
Responsibility: 
Suthagar Pillai Piaru, Roziahanim Mahmud, Amin Malik Shah Abdul Majid, Zeyad Daoud, Mahmoud Nassar
Abstract: Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods:he nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC(50) value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC(50) of 77.64 μg/mL comparing to mengkudu oil which exhibits IC(50) of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.
Keywords: Essential oil; antiangiogenic; antioxidant; myristica fragrans; morinda citrifolia
DOI: 10.1016/S1995-7645(12)60042-X
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