Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111848
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Antidepressant use in late gestation and breastfeeding rates at discharge from hospital
Author: Leggett, C.
Costi, L.
Morrison, J.
Clifton, V.
Grzeskowiak, L.
Citation: Journal of Human Lactation, 2017; 33(4):701-709
Publisher: Sage Science Press
Issue Date: 2017
ISSN: 0890-3344
1552-5732
Statement of
Responsibility: 
Catherine Leggett, Lynn Costi, Janna L. Morrison, Vicki L. Clifton, and Luke E. Grzeskowiak
Abstract: Background: Few studies have investigated breastfeeding outcomes among women exposed to antidepressants. Research aim: This study aimed to evaluate the association between antidepressant use in late gestation and maternal psychiatric illness on breastfeeding rates at discharge from hospital. Methods: The authors conducted a retrospective cohort study of 32,662 women delivering live-born singletons between January 2001 and December 2008. Electronic hospital records were used to obtain data on antidepressant exposure during late gestation and whether mothers were breastfeeding at discharge from hospital following delivery. Results: Five hundred seventy-five women received a dispensing for an antidepressant in late gestation (exposed), 1,552 did not receive a dispensing for an antidepressant but had a reported psychiatric illness (disease comparison), and 30,535 served as nonexposed controls. Exposed women were significantly less likely to be breastfeeding their infants at discharge from hospital compared with nonexposed women, adjusted odds ratio (AOR) = 0.63, 95% confidence interval (CI) [0.50-0.80], but no statistically significant difference was observed when compared with women in the disease comparison group, AOR = 0.83, 95% CI [0.65-1.07]. In stratified analyses, compared with women in the disease comparison group, exposed women were significantly less likely to be breastfeeding their infants at discharge from hospital if their neonate was delivered at term, AOR = 0.73, 95% CI [0.55-0.98], but not preterm, AOR = 1.24, 95% CI [0.66-2.32]. Conclusion: While antidepressant use is associated with a reduction in breastfeeding rates, this association appears to be strongly influenced by factors such as underlying maternal psychiatric illness. Overall, these results highlight that these women may benefit from additional education and support to improve breastfeeding rates.
Keywords: antidepressive agents; breastfeeding; lactation; prenatal care
Rights: © The Author(s) 2016
RMID: 0030076774
DOI: 10.1177/0890334416678209
Grant ID: http://purl.org/au-research/grants/nhmrc/1070421
http://purl.org/au-research/grants/nhmrc/1041918
Appears in Collections:Paediatrics publications

Files in This Item:
File Description SizeFormat 
hdl_111848.pdfAccepted version827.89 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.