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https://hdl.handle.net/2440/111892
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dc.contributor.author | McClure, B. | - |
dc.contributor.author | Heatley, S. | - |
dc.contributor.author | Kok, C. | - |
dc.contributor.author | Sadras, T. | - |
dc.contributor.author | An, J. | - |
dc.contributor.author | Hughes, T. | - |
dc.contributor.author | Lock, R. | - |
dc.contributor.author | Yeung, D. | - |
dc.contributor.author | Sutton, R. | - |
dc.contributor.author | White, D. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | British Journal of Cancer, 2018; 118(7):1000-1004 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.issn | 1532-1827 | - |
dc.identifier.uri | http://hdl.handle.net/2440/111892 | - |
dc.description.abstract | BACKGROUND: Zinc-finger protein 384 (ZNF384) fusions are an emerging subtype of precursor B-cell acute lymphoblastic leukaemia (pre-B-ALL) and here we further characterised their prevalence, survival outcomes and transcriptome. METHODS: Bone marrow mononuclear cells from 274 BCR-ABL1-negative pre-B-ALL patients were immunophenotyped and transcriptome molecularly characterised. Transcriptomic data was analysed by principal component analysis and gene-set enrichment analysis to identify gene and pathway expression changes. RESULTS: We exclusively detect E1A-associated protein p300 (EP300)-ZNF384 in 5.7% of BCR-ABL1-negative adolescent/young adult (AYA)/adult pre-B-ALL patients. EP300-ZNF384 patients do not appear to be a high-risk subgroup. Transcriptomic analysis revealed that EP300-ZNF384 samples have a distinct gene expression profile that results in the up-regulation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and cell adhesion pathways and down-regulation of cell cycle and DNA repair pathways. CONCLUSIONS: Importantly, this report contributes to a better overview of the incidence of EP300-ZNF384 patients and show that they have a distinct gene signature with concurrent up-regulation of JAK-STAT pathway, reduced expression of B-cell regulators and reduced DNA repair capacity. | - |
dc.description.statementofresponsibility | Barbara J. McClure, Susan L. Heatley, Chung H Kok, Teresa Sadras, Jiyuan An, Timothy P. Hughes, Richard B. Lock, David Yeung, Rosemary Sutton and Deborah L White | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © Cancer Research UK 2018 | - |
dc.source.uri | http://dx.doi.org/10.1038/s41416-018-0022-0 | - |
dc.subject | Humans | - |
dc.subject | Recurrence | - |
dc.subject | Trans-Activators | - |
dc.subject | Oncogene Proteins, Fusion | - |
dc.subject | Survival Analysis | - |
dc.subject | Gene Expression Profiling | - |
dc.subject | Signal Transduction | - |
dc.subject | Gene Expression Regulation, Leukemic | - |
dc.subject | Gene Frequency | - |
dc.subject | Genes, abl | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Child | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | STAT Transcription Factors | - |
dc.subject | E1A-Associated p300 Protein | - |
dc.subject | Janus Kinases | - |
dc.subject | Precursor Cell Lymphoblastic Leukemia-Lymphoma | - |
dc.subject | Young Adult | - |
dc.subject | Transcriptome | - |
dc.title | Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/s41416-018-0022-0 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1057746 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1044884 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McClure, B. [0000-0002-5201-4127] | - |
dc.identifier.orcid | Heatley, S. [0000-0001-7497-6477] | - |
dc.identifier.orcid | Kok, C. [0000-0002-3181-7852] | - |
dc.identifier.orcid | Hughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509] | - |
dc.identifier.orcid | Yeung, D. [0000-0002-7558-9927] | - |
dc.identifier.orcid | White, D. [0000-0003-4844-333X] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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