Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder
Author: Amare, A.
Schubert, K.
Tekola-Ayele, F.
Hsu, Y.
Sangkuhl, K.
Jenkins, G.
Whaley, R.
Barman, P.
Batzler, A.
Altman, R.
Arolt, V.
Brockmöller, J.
Chen, C.
Domschke, K.
Hall-Flavin, D.
Hong, C.
Illi, A.
Ji, Y.
Kampman, O.
Kinoshita, T.
et al.
Citation: Frontiers in Psychiatry, 2018; 9(MAR):65-1-65-11
Publisher: Frontiers Media
Issue Date: 2018
ISSN: 1664-0640
Statement of
Azmeraw T. Amare, Klaus Oliver Schubert, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Katrin Sangkuhl … Bernhard T. Baune … et al.
Abstract: Studies reported a strong genetic correlation between the Big Five personality traits and major depressive disorder (MDD). Moreover, personality traits are thought to be associated with response to antidepressants treatment that might partly be mediated by genetic factors. In this study, we examined whether polygenic scores (PGSs) derived from the Big Five personality traits predict treatment response and remission in patients with MDD who were prescribed selective serotonin reuptake inhibitors (SSRIs). In addition, we performed meta-analyses of genome-wide association studies (GWASs) on these traits to identify genetic variants underpinning the cross-trait polygenic association. The PGS analysis was performed using data from two cohorts: the Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS, n = 529) and the International SSRI Pharmacogenomics Consortium (ISPC, n = 865). The cross-trait GWAS meta-analyses were conducted by combining GWAS summary statistics on SSRIs treatment outcome and on the personality traits. The results showed that the PGS for openness and neuroticism were associated with SSRIs treatment outcomes at p < 0.05 across PT thresholds in both cohorts. A significant association was also found between the PGS for conscientiousness and SSRIs treatment response in the PGRN-AMPS sample. In the cross-trait GWAS meta-analyses, we identified eight loci associated with (a) SSRIs response and conscientiousness near YEATS4 gene and (b) SSRI remission and neuroticism eight loci near PRAG1, MSRA, XKR6, ELAVL2, PLXNC1, PLEKHM1, and BRUNOL4 genes. An assessment of a polygenic load for personality traits may assist in conjunction with clinical data to predict whether MDD patients might respond favorably to SSRIs.
Keywords: antidepressants; major depression; personality traits; pharmacogenomics; polygenic score; selective serotonin reuptake inhibitors
Rights: Copyright © 2018 Amare, Schubert, Tekola-Ayele, Hsu, Sangkuhl, Jenkins, Whaley, Barman, Batzler, Altman, Arolt, Brockmöller, Chen, Domschke, Hall-Flavin, Hong, Illi, Ji, Kampman, Kinoshita, Leinonen, Liou, Mushiroda, Nonen, Skime, Wang, Kato, Liu, Praphanphoj, Stingl, Bobo, Tsai, Kubo, Klein, Weinshilboum, Biernacka and Baune. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030083985
DOI: 10.3389/fpsyt.2018.00065
Appears in Collections:Psychology publications

Files in This Item:
File Description SizeFormat 
hdl_112033.pdfPublished version1.09 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.