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Type: Journal article
Title: Gastrointestinal symptoms in diabetes: prevalence, assessment, pathogenesis, and management
Author: Du, Y.
Rayner, C.
Jones, K.
Talley, N.
Horowitz, M.
Citation: Diabetes Care, 2018; 41(3):627-637
Publisher: American Diabetes Association
Issue Date: 2018
ISSN: 0149-5992
Statement of
Yang T. Du, Christopher K. Rayner, Karen L. Jones, Nicholas J. Talley and Michael Horowitz
Abstract: "If you haven't measured something, you really don't know much about it." -Karl Pearson (attributed). Gastrointestinal (GI) symptoms represent an important and often unappreciated cause of morbidity in diabetes, although the significance of this burden across the spectrum of patients and the underlying pathophysiology, including the relationship of symptoms with glycemic control, remain poorly defined. The relevance of GI symptoms and the necessity for their accurate assessment have increased with the greater focus on the gut as a therapeutic target for glucose lowering. This review addresses the prevalence, assessment, pathogenesis, and management of GI symptoms in diabetes, beginning with broad principles and then focusing on specific segments of the GI tract. We initially performed a literature search of PubMed by using synonyms and combinations of the following search terms: "gastrointestinal symptoms", "diabetes", "prevalence", "pathogenesis", "diagnosis", and "management". We restricted the search results to English only. Review papers and meta-analyses are presented as the highest level of evidence where possible followed by randomized controlled trials, uncontrolled trials, retrospective and observational data, and expert opinion.
Keywords: Humans; Gastrointestinal Diseases; Diabetes Mellitus; Prevalence; Disease Management; Randomized Controlled Trials as Topic
Rights: © 2018 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at
RMID: 0030083363
DOI: 10.2337/dc17-1536
Grant ID:
Appears in Collections:Medicine publications

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